2,4,6-三氟-N-[6-[(1-甲基-4-哌啶基)羰基]-2-吡啶基]苯甲酰胺
更新时间：2026-03-10 11:10:38
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| 常用名 | 2,4,6-三氟-N-[6-[(1-甲基-4-哌啶基)羰基]-2-吡啶基]苯甲酰胺 | CAS号 | 439239-90-4 |
|---|---|---|---|
| 价格 | ￥需询单/200kg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Lasmiditan (COL-144; LY573144) is a high-affinity, highly selective 5-HT1F receptor agonist(Ki=2.1 nM), compared with Ki of 1043 nM and 1357 nM at the 5-HT(1B) and 5-HT(1D) receptors, respectively.IC50 value: 2.1 nM (Ki, 5-HT1F); >1000 nM (Ki, 5-HT1B/5-HT1D) [1]Target: 5-HT1F receptorin vitro: In vitro binding studies Lasmiditan showed a K(i) value of 2.21 nM at the 5-HT(1F) receptor, compared with K(i) values of 1043 nM and 1357 nM at the 5-HT(1B) and 5-HT(1D) receptors, respectively, a selectivity ratio greater than 470-fold. Lasmiditan showed higher selectivity for the 5-HT(1F) receptor relative to other 5-HT(1) receptor subtypes than the first generation 5-HT(1F) receptor agonist LY334370. Unlike the 5-HT(1B/1D) receptor agonist sumatriptan, lasmiditan did not contract rabbit saphenous vein rings, a surrogate assay for human coronary artery constriction, at concentrations up to 100 μM [1].in vivo: In two rodent models of migraine, oral administration of lasmiditan potently inhibited markers associated with electrical stimulation of the trigeminal ganglion (dural plasma protein extravasation, and induction of the immediate early gene c-Fos in the trigeminal nucleus caudalis) [1]. Two RCTs in the phase II development of lasmiditan was reviewed. In the intravenous placebo-controlled RCT, lasmiditan doses of 2.5-45 mg were used, and there was a linear association between headache relief (HR) rates and dose levels (P 物理化学性质： CAS号：439239-90-4 常用中文名：2,4,6-三氟-N-[6-[(1-甲基-4-哌啶基)羰基]-2-吡啶基]苯甲酰胺 常用英文名：Lasmiditan 分子式：C19H18F3N3O2 分子量：377.360 密度：1.4±0.1 g/cm3 沸点：433.3±45.0 °C at 760 mmHg 熔点：N/A 闪点：215.9±28.7 °C 储存条件：2-8℃ |
苏州市森菲达化工有限公司
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商品数：20000件
电话：0512-18796480002
地址：苏州市高新区浒墅关经济技术开发区
地区： 江苏省 苏州市 相城区
联系人：程经理
联系人电话：18796480002
邮件：13771713870@163.com
网址：http://www.senfeida.com
主要市场：国内，海外
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- 苏州市森菲达化工有限公司
- 江苏省 苏州市 相城区
- 产品名：2,4,6-三氟-N-[6-[(1-甲基-4-哌啶基)羰基]-2-吡啶基]苯甲酰胺
- 价格： ￥需询单/200kg
- 纯度：98.0%
- 备货期：需询单
- 联系人：程经理
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：Lasmiditan (COL-144; LY573144)
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
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参考价格：$96/2mg