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Triazole-Diindolylmethane Conjugates as New Antitubercular Agents: Synthesis, Bioevaluation and Molecular Docking
10.1039/C8MD00055G 2018-04-11 We have described the synthesis of novel triazole incorporated diindolylmethanes (DIMs) using molecular hybridization approach and their in vitro antitubercular activity against Mycobacterium tuberculosis H37Ra (ATCC 25177) both in active and dormant state. A... |
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Design, synthesis and antimicrobial activity of usnic acid derivatives
10.1039/C8MD00076J 2018-04-11 Usnic acid, a dibenzofuran, was originally isolated from lichens belonging to secondary metabolites, and is well known as an antibiotic, but also endowed with several other interesting properties. Thus the goal of this paper is the design of new usnic acid de... |
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Correction: The critical role of novel benzophenone analogs on tumor growth inhibition targeting angiogenesis and apoptosis
10.1039/C8MD90018C 2018-04-10 Correction for ‘The critical role of novel benzophenone analogs on tumor growth inhibition targeting angiogenesis and apoptosis’ by Yasser Hussein Eissa Mohammed et al., Med. Chem. Commun., 2018, DOI: 10.1039/c7md00593h. |
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Outstanding Reviewers for MedChemComm in 2017
10.1039/C8MD90017E 2018-04-10 A graphical abstract is available for this content |
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Design, synthesis and biological evaluation of novel 1,3-diarylpyrazoles as cyclooxygenase inhibitors, antiplatelet and anticancer agents
10.1039/C8MD00022K 2018-04-06 With the aim of achieving new compounds possessing both anti-inflammatory and antiplatelet activities, we synthesized (E)-3-[3-(pyridin-3/4-yl)-1-(phenyl/sulfonylmethylphenyl)-1H-pyrazol-4-yl]acrylamides, and evaluated their COX-1 and COX-2 inhibitory and ant... |
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Development of piperazine-1-carbothioamide chitosan silver nanoparticles (P1C-Tit*CAgNPs) as a promising anti-inflammatory candidate: a molecular docking validation
10.1039/C7MD00628D 2018-04-04 Natural products are important leads in drug discovery. The search for effective plant-derived agents or their synthetic analogues has continued to be of interest to biologists and chemists for a long time. Herein, we have synthesized a novel compound, P1C, a... |
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Synthesis and Biological Evaluation of New 3-amino-2-azetidinone Derivatives as anti-colorectal cancer agents
10.1039/C8MD00147B 2018-04-04 Several synthetic Combretastatin A4 (CA-4) derivatives were recently prepared to increase drug efficacy and stability of the natural product isolated from South African tree Combretum caffrum. A group of ten 3-amino-2-azetidinone derivatives, as Combretastati... |
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New tetrahydroisoquinoline based P-glycoprotein modulators: decoration of the biphenyl core gives selective ligands.
10.1039/C8MD00075A 2018-04-03 P-glycoprotein (P-gp, MDR1) is a membrane transporter expressed in several districts of our body. It exerts a crucial defense role as it effluxes hundreds of potentially toxic substances. Hovewer, P-gp is one of the main causes of the failure in cancer chemot... |
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Effect of isouronium/guanidinium substitution on the efficacy of a series of novel anti-cancer agents
10.1039/C8MD00089A 2018-03-27 Considering our hypothesis that the guanidinium moiety in the protein kinase type III inhibitor 1 interacts with a phosphate of ATP within the hinge region, the nature of the interactions established between a model isouronium and the phosphate groups of ATP ... |
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Correction: Conformationally restricted benzothienoazepine respiratory syncytial virus inhibitors: their synthesis, structural analysis and biological activities
10.1039/C8MD90016G 2018-03-26 Correction for ‘Conformationally restricted benzothienoazepine respiratory syncytial virus inhibitors: their synthesis, structural analysis and biological activities’ by Euan A. F. Fordyce et al., Med. Chem. Commun., 2018, DOI: 10.1039/c8md00033f. |