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Palladium-catalyzed direct approach to α-CF3 aryl ketones from arylboronic acids
10.1039/C8QO00289D 2018-03-30 A concise and practical method for the synthesis of α-CF3 aryl ketones using stable and commercially available arylboronic acids and ICH2CF3 was reported. The α-CF3 aryl ketones could be easily obtained using a CO balloon (1 atm) in the presence of a palladiu... |
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Selective remote C–H trifluoromethylation of aminoquinolines with CF3SO2Na under visible light irradiation in the absence of an external photocatalyst
10.1039/C8QO00229K 2018-03-30 A highly selective remote C–H trifluoromethylation of 8-aminoquinoline scaffolds in the C5-position with CF3SO2Na under visible light irradiation without an external photocatalyst has been developed. The protocol employs commercially available sodium trifluor... |
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Copper/amine-catalyzed formal regioselective [3 + 2] cycloaddition of an α,β-unsaturated O-acetyl oxime with enals
10.1039/C8QO00204E 2018-03-29 A novel copper/amine co-catalyzed formal regioselective [3 + 2] cycloaddition reaction of an O-acyl oxime with α,β-unsaturated aldehydes is developed. This novel transformation provided an efficient protocol for the assembly of multifunctionalized pyrroles wi... |
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Nickel-catalyzed enantioselective sequential Nazarov cyclization/decarboxylation
10.1039/C8QO00279G 2018-03-29 The nickel-catalyzed enantioselective sequential Nazarov cyclization/decarboxylation has been developed. The use of chiral oxazoline iminopyridine and metal perchlorate allows the enantioselective decarboxylative electrocyclization of divinyl ketones bearing ... |
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Rh(III)-Catalyzed synthesis of pyrazolo[1,2-a]cinnolines from pyrazolidinones and diazo compounds
10.1039/C8QO00209F 2018-03-28 Rhodium(III)-catalyzed redox-neutral annulation of pyrazolidinones with diazo compounds has been described. This reaction provides a straightforward platform to access various pyrazolo[1,2-a]cinnolines, which have potential medicinal value, under mild reactio... |
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Rhodium-catalyzed decarbonylative cycloadditions of 1H-indene-1,2,3-triones and alkynes via direct C–C bond activation: divergent synthesis of indenones and quinones
10.1039/C8QO00186C 2018-03-28 A one-step preparation method for indenone and quinone derivatives via rhodium-mediated [5 + 2 − 2] and [5 + 2 − 1] decarbonylative cycloadditions of 1H-indene-1,2,3-triones and alkynes has been achieved. A rhodium(I) complex, [Rh(COD)Cl]2, with a bisphosphin... |
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A general approach for the formation of oxygen-chelated ruthenium alkylidene complexes relying on the Thorpe–Ingold effect
10.1039/C8QO00160J 2018-03-28 Ruthenium alkylidene complexes are prepared via enyne ring-closing metathesis relying on the exo and endo gem-dialkyl substituent effect. The structural features stabilizing oxygen-chelates are explored and confirmed by single crystal X-ray diffraction analys... |
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Computational study on GaCl3-mediated reactions of donor–acceptor cyclopropanes with aromatic aldehydes: mechanism and role of GaCl3 and aldehydes
10.1039/C8QO00243F 2018-03-28 By means of density functional theory (DFT), the mechanism and role of GaCl3 and aldehydes for the GaCl3-mediated reaction of donor–acceptor (D–A) cyclopropanes and arylaldehydes have been reported in this work. DFT calculations reveal that the title reaction... |
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Catalytic enantioselective synthesis of α-chiral azides
10.1039/C8QO00138C 2018-03-27 α-Chiral azides represent a special subclass of chiral amines, which not only widely exist in bioactive compounds but also play a significant role as a building block in a variety of value-added chiral products. The catalytic asymmetric synthesis of α-chiral ... |
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Photo-induced C–H bond activation of N,N′-dialkylethylenediamine upon aza-Michael addition to 1,8-pyrenedione: facile synthesis of fluorescent pyrene derivatives
10.1039/C8QO00183A 2018-03-27 We discovered a reaction between 1,8-pyrenedione and N,N′-dialkylethylenediamine to form highly fluorescent products, via aza-Michael addition followed by double C–H activation facilitated by visible light. Remarkably, the reaction intermediates and mono C–H ... |