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UCN-01

UCN-01用途

UCN-01 (7-Hydroxystaurosporine.

UCN-01名称

[ CAS 号 ]:
112953-11-4

[ 英文名 ]:
UCN-01

[英文别名 ]:

UCN-01
1okz

UCN-01物理化学性质

[ 密度 ]:
1.63g/cm3

[ 沸点 ]:
705.7ºC at 760mmHg

[ 分子式 ]:
C₂₈H₂₆N₄O₄

[ 分子量 ]:
482.53000

[ 闪点 ]:
380.6ºC

[ 精确质量 ]:
482.19500

[ PSA ]:
89.68000

[ LogP ]:
4.56460

[ 外观性状 ]:
浅黄色固体

[ 蒸汽压 ]:
6.64E-21mmHg at 25°C

[ 折射率 ]:
1.827

[ 储存条件 ]:
-20°C

UCN-01毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KC6600010

CAS REGISTRY NUMBER :: 112953-11-4

LAST UPDATED :: 199312

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C28-H26-N4-O4

MOLECULAR WEIGHT :: 482.58

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 42,571,1989

UCN-01安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
KC6600010

UCN-01文献

Nitric oxide donors increase PVR/CD155 DNAM-1 ligand expression in multiple myeloma cells: role of DNA damage response activation.

BMC Cancer 15 , 17, (2015)

DNAX accessory molecule-1 (DNAM-1) is an activating receptor constitutively expressed by macrophages/dendritic cells and by T lymphocytes and Natural Killer (NK) cells, having an important role in ant...

Induction of DNA damage and G2 cell cycle arrest by diepoxybutane through the activation of the Chk1-dependent pathway in mouse germ cells.

Chem. Res. Toxicol. 28(3) , 518-31, (2015)

1,2:3,4-Diepoxybutane (DEB) is a major carcinogenic metabolite of 1,3-butadiene (BD), which has been shown to cause DNA strand breaks in cells through its potential genotoxicity. The adverse effect of...

The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux.

Autophagy 11 , 1373-88, (2015)

Oncogenic mutation of KRAS (Kirsten rat sarcoma viral oncogene homolog) in colorectal cancer (CRC) confers resistance to both chemotherapy and EGFR (epidermal growth factor receptor)-targeted therapy....

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