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2,2-二氯联苯

2,2-二氯联苯名称

[ CAS 号 ]:
13029-08-8

[ 中文名 ]:
2,2’-二氯联苯

[ 英文名 ]:
2,2'-DICHLOROBIPHENYL

[中文别名 ]:

[英文别名 ]:

1-chloro-2-(2-chlorophenyl)benzene

2,2-二氯联苯物理化学性质

[ 密度 ]:
1.249g/cm3

[ 沸点 ]:
289.1ºC at 760mmHg

[ 熔点 ]:
79-80℃ (hexane )

[ 分子式 ]:
C₁₂H₈Cl₂

[ 分子量 ]:
223.09800

[ 闪点 ]:
122.4ºC

[ 精确质量 ]:
222.00000

[ LogP ]:
4.66040

[ 蒸汽压 ]:
0.00389mmHg at 25°C

[ 折射率 ]:
1.594

2,2-二氯联苯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DV3900000

CHEMICAL NAME :: Biphenyl, 2,2'-dichloro-

CAS REGISTRY NUMBER :: 13029-08-8

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C12-H8-Cl2

MOLECULAR WEIGHT :: 223.10

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 mg/kg/3D-I

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 33,94,1975

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 25 mg/kg/20D-I

TOXIC EFFECTS :: Immunological Including Allergic - decrease in humoral immune response

REFERENCE :: JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984- Volume(issue)/page/year: 9,283,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 25 mg/kg/20D-I

TOXIC EFFECTS :: Liver - other changes

REFERENCE :: JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984- Volume(issue)/page/year: 12,17,1993 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1125 mg/kg

SEX/DURATION :: female 1-3 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 40,249,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1500 mg/kg

SEX/DURATION :: female 1-3 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 40,249,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1125 mg/kg

SEX/DURATION :: female 1-3 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition

REFERENCE :: BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 16,33,1976

2,2-二氯联苯安全信息

[ 符号 ]:

GHS08, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H373-H410

[ 警示性声明 ]:
P273-P391-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
N: Dangerous for the environment;

[ 风险声明 (欧洲) ]:
R33

[ 安全声明 (欧洲) ]:
S35

[ 危险品运输编码 ]:
UN 2315

[ RTECS号 ]:
DV3900000

[ 包装等级 ]:
II

2,2-二氯联苯合成路线

详细合成路线

2,2-二氯联苯文献

Structural characterization of Pandoraea pnomenusa B-356 biphenyl dioxygenase reveals features of potent polychlorinated biphenyl-degrading enzymes.

PLoS ONE 8(1) , e52550, (2013)

The oxidative degradation of biphenyl and polychlorinated biphenyls (PCBs) is initiated in Pandoraea pnomenusa B-356 by biphenyl dioxygenase (BPDO(B356)). BPDO(B356), a heterohexameric (αβ)(3) Rieske ...

Possible molecular targets of halogenated aromatic hydrocarbons in neuronal cells.

Biochem. Biophys. Res. Commun. 280(5) , 1372-7, (2001)

Halogenated aromatic hydrocarbon including polychlorinated biphenyls (PCBs) are persistent and bioaccumulative environmental toxicants. Although health effects associated with exposure to these chemic...

Comparative toxicokinetics of 2,2'- and 4,4'-dichlorobiphenyls in the pond snail Lymnaea stagnalis (L.).

Arch. Environ. Contam. Toxicol. 19(4) , 565-71, (1990)

Pond snails (Lymnaea stagnalis (L.)) were treated with 2,2'-dichlorobiphenyl (DCB) or 4,4'-DCB, to examine the toxicokinetic profile of these compounds. Snails were treated orally with 210 micrograms ...

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