2,2-二氯联苯
2,2-二氯联苯结构式
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常用名 | 2,2-二氯联苯 | 英文名 | 2,2'-DICHLOROBIPHENYL |
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| CAS号 | 13029-08-8 | 分子量 | 223.09800 | |
| 密度 | 1.249g/cm3 | 沸点 | 289.1ºC at 760mmHg | |
| 分子式 | C12H8Cl2 | 熔点 | 79-80℃ (hexane ) | |
| MSDS | 中文版 美版 | 闪点 | 122.4ºC | |
| 符号 |
GHS08, GHS09 |
信号词 | Warning |
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Structural characterization of Pandoraea pnomenusa B-356 biphenyl dioxygenase reveals features of potent polychlorinated biphenyl-degrading enzymes.
PLoS ONE 8(1) , e52550, (2013) The oxidative degradation of biphenyl and polychlorinated biphenyls (PCBs) is initiated in Pandoraea pnomenusa B-356 by biphenyl dioxygenase (BPDO(B356)). BPDO(B356), a heterohexameric (αβ)(3) Rieske oxygenase (RO), catalyzes the insertion of dioxygen with st... |
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Possible molecular targets of halogenated aromatic hydrocarbons in neuronal cells.
Biochem. Biophys. Res. Commun. 280(5) , 1372-7, (2001) Halogenated aromatic hydrocarbon including polychlorinated biphenyls (PCBs) are persistent and bioaccumulative environmental toxicants. Although health effects associated with exposure to these chemicals, including motor dysfunction and impairment in memory a... |
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Comparative toxicokinetics of 2,2'- and 4,4'-dichlorobiphenyls in the pond snail Lymnaea stagnalis (L.).
Arch. Environ. Contam. Toxicol. 19(4) , 565-71, (1990) Pond snails (Lymnaea stagnalis (L.)) were treated with 2,2'-dichlorobiphenyl (DCB) or 4,4'-DCB, to examine the toxicokinetic profile of these compounds. Snails were treated orally with 210 micrograms 4,4'-DCB (impregnated on food) for 14 hr, or snails were in... |
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Alteration of regiospecificity in biphenyl dioxygenase by active-site engineering.
J. Bacteriol. 184(13) , 3682-8, (2002) Biphenyl dioxygenase (Bph Dox) is responsible for the initial dioxygenation step during the metabolism of biphenyl. The large subunit (BphA1) of Bph Dox plays a crucial role in the determination of the substrate specificity of biphenyl-related compounds, incl... |
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Revisiting the regiospecificity of Burkholderia xenovorans LB400 biphenyl dioxygenase toward 2,2'-dichlorobiphenyl and 2,3,2',3'-tetrachlorobiphenyl.
J. Biol. Chem. 279(46) , 47489-96, (2004) 2,2'-Dichlorobiphenyl (CB) is transformed by the biphenyl dioxygenase of Burkholderia xenovorans LB400 (LB400 BPDO) into two metabolites (1 and 2). The most abundant metabolite, 1, was previously identified as 2,3-dihydroxy-2'-chlorobiphenyl and was presumed ... |
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Potential role for oxidative stress in 2,2'-dichlorobiphenyl-induced inhibition of uterine contractions but not myometrial gap junctions.
Toxicol. Sci. 93(1) , 172-9, (2006) Previously, we reported that 2,2'-dichlorobiphenyl (2,2'-DCB)-induced decreases of amplitude and synchronization of uterine contractions are dependent on MAPK-induced phosphorylation of Connexin43 (Cx43) and inhibition of myometrial gap junctions. Recent stud... |
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Occurrence of a cytochrome P-450-containing mixed-function oxidase system in the pond snail, Lymnaea stagnalis.
Xenobiotica 21(2) , 223-33, (1991) 1. The occurrence of an as yet unidentified cytochrome P-450 in the microsomal fraction of the digestive gland of the snail, Lymnaea stagnalis was studied. 2. Studies in vivo and in vitro (digestive gland homogenates or the 170,000g fraction) of the cytochrom... |
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2,2'-Dichlorobiphenyl decreases amplitude and synchronization of uterine contractions through MAPK1-mediated phosphorylation of GJA1 (connexin43) and inhibition of myometrial gap junctions.
Biol. Reprod. 73(5) , 974-82, (2005) The present study examined the hypothesis that inhibition of myometrial gap junctions through MAPK1-induced phosphorylation of GJA1 (connexin43) leads to inhibition of spontaneous phasic uterine contractions by 2,2'-dichlorobiphenyl (2,2'-DCB). Uterine strips... |
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Neurotoxicity of polychlorinated biphenyls: structure-activity relationship of individual congeners.
Toxicol. Appl. Pharmacol. 111(1) , 33-42, (1991) Neurotoxicity of Polychlorinated Biphenyls: Structure-Activity Relationship of Individual Congeners, Shain, W., Bush, B., Seegal, R. (1991). Toxicol. Appl. Pharmacol. 111, 33-42. Experimental and epidemiological data indicate that polychlorinated biphenyls (P... |
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Comparative effects of two polychlorinated biphenyl congeners on calcium homeostasis in rat cerebellar granule cells.
Toxicol. Appl. Pharmacol. 123(1) , 97-106, (1993) Some polychlorinated biphenyls (PCBs) have been reported to alter locomotor activity and decrease brain dopamine function in laboratory animals. PCBs with ortho- and/or parachlorine substitutions and varying number of chlorinations are known to decrease cell ... |