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水飞蓟宾B

水飞蓟宾B用途

Silybin B 是从 Silybum marianum 中分离出的一种黄酮木脂素,具有抗肿瘤活性。Silybin B 是水飞蓟素最有效的抗纤维原性和抗低聚物成分,是一种有前景的抗阿尔茨海默病药物候选。

水飞蓟宾B名称

[ CAS 号 ]:
142797-34-0

[ 中文名 ]:
水飞蓟宾A+B

[ 英文名 ]:
Silybin B

[英文别名 ]:

MFCD03225424
SILIBININ A
EINECS 245-302-5
Silibinin
Silybin
Silybum Substance E6
33X338MNE4
MFCD00872186
Dura-Silymarin

水飞蓟宾B生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 神经疾病

[参考文献]

[1]. An-Shen Lin, et al. Cancer Preventive Agents. 7. Antitumor-Promoting Effects of Seven Active Flavonolignans from Milk Thistle (Silybum marianum.) on Epstein-Barr Virus Activation, Pharmaceutical Biology, 45:10, 735-738.

[2]. Sciacca MFM, et al. Inhibition of Aβ Amyloid Growth and Toxicity by Silybins: The Crucial Role of Stereochemistry. ACS Chem Neurosci. 2017 Aug 16;8(8):1767-1778.

水飞蓟宾B物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
793.0±60.0 °C at 760 mmHg

[ 熔点 ]:
158-160℃ (methanol water )

[ 分子式 ]:
C₂₅H₂₂O₁₀

[ 分子量 ]:
482.436

[ 闪点 ]:
274.5±26.4 °C

[ 精确质量 ]:
482.121307

[ LogP ]:
2.59

[ 蒸汽压 ]:
0.0±2.9 mmHg at 25°C

[ 折射率 ]:
1.684

[ 储存条件 ]:
2-8°C

水飞蓟宾B安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

水飞蓟宾B文献

Identification of diet-derived constituents as potent inhibitors of intestinal glucuronidation.

Drug Metab. Dispos. 42(10) , 1675-83, (2014)

Drug-metabolizing enzymes within enterocytes constitute a key barrier to xenobiotic entry into the systemic circulation. Furanocoumarins in grapefruit juice are cornerstone examples of diet-derived xe...

Isolation and purification of diastereoisomeric flavonolignans from silymarin by binary-column recycling preparative high-performance liquid chromatography.

J. Sep. Sci. 37(17) , 2300-6, (2014)

Silymarin extracted from Silybum marianum (L.) Gaertn consists of a large number of flavonolignans, of which diastereoisomeric flavonolignans including silybin A and silybin B, and isosilybin A and is...

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