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(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P acetate

用途

(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P (acetate) 是神经肽 P (Substance P) (HY-P0201) 和蛙皮素 (Bombesin) (HY-P0195) 的拮抗剂,对眼部逆向三叉神经刺激的炎症反应有作用。

名称

[ CAS 号 ]:
143077-65-0

[ 英文名 ]:
(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P acetate

生物活性

[ 描述 ]:

(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P (acetate) 是神经肽 P (Substance P) (HY-P0201) 和蛙皮素 (Bombesin) (HY-P0195) 的拮抗剂,对眼部逆向三叉神经刺激的炎症反应有作用。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他
研究领域 >> 炎症/免疫
研究领域 >> 神经疾病

[参考文献]

[1]. A Mandahl, A Bill, et al. Effects of the substance P antagonist, (D-Arg1, D-Pro2, D-Trp7,9, Leu11)-SP on the miotic response to substance P, antidromic trigeminal nerve stimulation, capsaicin, prostaglandin E1, compound 48/80 and histamine. Acta Physiol Scand. 1984 Jan;120(1):27-35.  

物理化学性质

[ 分子式 ]:
C77H112N20O15

[ 分子量 ]:
1557.84000

[ 精确质量 ]:
1556.86000

[ PSA ]:
585.51000

[ LogP ]:
7.15190

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

文献

Neuromedin B stimulates arachidonic acid release, c-fos gene expression, and the growth of C6 glioma cells.

Peptides 16 , 1133-1140, (1995)

The effects of neuromedin B (NMB) on C6 glioma cells were investigated. NMB bound with high affinity (IC50 = 1 nM) to C6 cells whereas BN and GRP were less potent (IC50 = 40 and 100 nM). NMB (1 nM) el...

A new paradigm for stem cell therapy: substance-P as a stem cell-stimulating agent.

Arch. Pharm. Res. 34 , 2003-2006, (2011)

Bone marrow is a reservoir for hematopoietic stem cells, endothelial precursor cells, and bone marrow stromal cells (also generally called mesenchymal stem cells), whose positive role in tissue repair...

Substance P mechanisms in the regulation of striated muscle microcirculation.

Microvasc. Res. 41 , 24-28, (1991)

The effects of substance P (SP) on microvessels in the cremaster of sodium pentobarbital-anesthetized male, Sprague-Dawley rats were investigated using closed-circuit television microscopy. Topically ...


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相关化合物

CAS号[143077-65-0]化源网提供[(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P acetate]MSDS、说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。>>电脑版:(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P acetate

标题:【(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P acetate】(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P acetate CAS号:143077-65-0【结构式 性质 活性】-化源网 地址:https://www.chemsrc.com/amp/cas/143077-65-0_954430.html