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1-(4-氟苯基)哌嗪

1-(4-氟苯基)哌嗪名称

[ CAS 号 ]:
2252-63-3

[ 中文名 ]:
1-(4-氟苯基)哌嗪

[ 英文名 ]:
1-(4-Fluorophenyl)piperazine

[中文别名 ]:

[英文别名 ]:

Flipiperazine
1-(4-fluoro-phenyl)piperazine
4-(4-fluorophenyl)-piperazine
1-(p-Fluorophenyl)piperazine
N-(4-Fluorophenyl)piperazine
4-fluorophenylpiperazine
p-Fluorophenylpiperazine
para-fluorophenylpiperazine
EINECS 218-846-6
MFCD00005960

1-(4-氟苯基)哌嗪物理化学性质

[ 密度 ]:
1.0

[ 沸点 ]:
118-123 °C0.1 mm Hg(lit.)

[ 熔点 ]:
30-33 °C(lit.)

[ 分子式 ]:
C₁₀H₁₃FN₂

[ 分子量 ]:
180.22200

[ 闪点 ]:
>230 °F

[ 精确质量 ]:
180.10600

[ PSA ]:
15.27000

[ LogP ]:
1.62910

[ 外观性状 ]:
透明淡黄色液体在熔点后

[ 蒸汽压 ]:
1.78E-05mmHg at 25°C

[ 折射率 ]:
1.5585-1.5605

[ 储存条件 ]:
Refrigerator

1-(4-氟苯基)哌嗪MSDS

1-(4-氟苯基)哌嗪安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
2811

[ WGK德国 ]:
2

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2933599090

1-(4-氟苯基)哌嗪合成路线

1-(4-氟苯基)哌嗪上下游产品

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1-(4-氟苯基)哌嗪海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1-(4-氟苯基)哌嗪文献

Antagonist but not agonist labeling of serotonin-1A receptors is decreased in major depressive disorder.

J. Psychiatr. Res. 43(10) , 887-94, (2009)

Serotonin-1A receptors may play a role in the pathophysiology of depression and suicide. In postmortem brain tissue, agonist binding to serotonin-1A receptors is reportedly increased or unchanged in d...

The effect of niaprazine on the turnover of 5-hydroxytryptamine in the rat brain.

Neuropharmacology 21(2) , 163-9, (1982)

Niaprazine (60 mg/kg i.p.) increased rat brain 5-hydroxyindole acetic acid (5-HIAA) concentrations 30 min after treatment, and reduced them at 3-8 hr after treatment. Rat brain 5-hydroxytryptamine (5-...

Rapid synthesis of N, N'-disubstituted piperazines. Application to the preparation of No carrier added 1-(4-[18F] fluorophenyl) piperazine and of an [18F]-selective ligand of serotoninergic receptors (5HT2 antagonist). Collins M, et al.

J. Chem. Soc. Perkin Trans. I 23 , 3185-88, (1992)

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