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5-氨基-5-脱氧胸腺嘧啶脱氧核苷

5-氨基-5-脱氧胸腺嘧啶脱氧核苷用途

5′-氨基-5′-脱氧胸苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

5-氨基-5-脱氧胸腺嘧啶脱氧核苷名称

[ CAS 号 ]:
25152-20-9

[ 中文名 ]:
5-氨基-5-脱氧胸腺嘧啶脱氧核苷

[ 英文名 ]:
Thymidine,5'-amino-5'-deoxy-

[英文别名 ]:

5'-Amino-5'-deoxy-D-thymidine
5'-amino-3'-hydroxythymidine
5'-amino-5'-deoxy-thymidine
5'-deoxy-5'-aminothymidine
5'-deoxy-5'-amino-deoxythymidine

5-氨基-5-脱氧胸腺嘧啶脱氧核苷生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

[参考文献]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

5-氨基-5-脱氧胸腺嘧啶脱氧核苷物理化学性质

[ 密度 ]:
1.394 g/cm3

[ 分子式 ]:
C₁₀H₁₅N₃O₄

[ 分子量 ]:
241.24

[ 精确质量 ]:
241.10600

[ PSA ]:
110.34000

[ 折射率 ]:
1.565

5-氨基-5-脱氧胸腺嘧啶脱氧核苷MSDS

5-氨基-5-脱氧胸腺嘧啶脱氧核苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

5-氨基-5-脱氧胸腺嘧啶脱氧核苷合成路线

5-氨基-5-脱氧胸腺嘧啶脱氧核苷上下游产品

5-氨基-5-脱氧胸腺嘧啶脱氧核苷上游产品

5-氨基-5-脱氧胸腺嘧啶脱氧核苷下游产品

5-氨基-5-脱氧胸腺嘧啶脱氧核苷文献

Measurement of carbamoylating activity of nitrosoureas and isocyanates by a novel high-pressure liquid chromatography assay.

Biochem. Pharmacol. 35(14) , 2359-65, (1986)

A new assay for carbamoylating activity using reversed phase liquid chromatography (HPLC) is described which offers several advantages over existing assays. A comparison was made of the extent of carb...

Novel acyclic amide-conjugated nucleosides and their analogues.

Nucleosides Nucleotides Nucleic Acids 28 , 103-117, (2009)

An effective one-step synthesis of new amide-conjugated nucleosides and their analogues, in the presence of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM) as the condensin...

Carbamoylation reactions of N-methyl-N'-aryl-N-nitrosoureas and corresponding phenyl isocyanates to 5'-amino-5'-deoxythymidine: importance of carbamoylation in mouse skin carcinogenic processes.

Carcinogenesis 13(4) , 699-702, (1992)

Carbamoylation reactions of N-methyl-N'-aryl-N-nitrosoureas (I-X: X = -OCH3, -CH3, -H, -Cl, and -COCH3) and of their corresponding phenyl isocyanates (II-X: X = -OCH3, -CH3, -H, -Cl and -COCH3) to the...

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