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Prostaglandin F2α methyl ester

Prostaglandin F2α methyl ester名称

[ CAS 号 ]:
33854-16-9

[ 英文名 ]:
Prostaglandin F2α methyl ester

[英文别名 ]:

prostaglandins f2alpha methyl ester

Prostaglandin F2α methyl ester物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
494.2±45.0 °C at 760 mmHg

[ 分子式 ]:
C₂₁H₃₆O₅

[ 分子量 ]:
368.508

[ 闪点 ]:
161.9±22.2 °C

[ 精确质量 ]:
368.256287

[ PSA ]:
86.99000

[ LogP ]:
2.70

[ 蒸汽压 ]:
0.0±2.8 mmHg at 25°C

[ 折射率 ]:
1.548

Prostaglandin F2α methyl esterMSDS

Prostaglandin F2α methyl ester毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UK8021500

CHEMICAL NAME :: Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, methyl ester, (5Z,9-alpha,11-alpha, 13E,15S)-

CAS REGISTRY NUMBER :: 33854-16-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C21-H36-O5

MOLECULAR WEIGHT :: 368.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravaginal

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 80 ug/kg

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting

REFERENCE :: JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year: 102,620,1983 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravaginal

DOSE :: 80 ug/kg

SEX/DURATION :: female 7 week(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year: 102,620,1983

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 480 ug/kg

SEX/DURATION :: female 4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 186,67,1973

Prostaglandin F2α methyl ester安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H319-H336

[ 补充危害声明 ]:
Repeated exposure may cause skin dryness or cracking.

[ 警示性声明 ]:
P210-P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313-P403 + P235

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
F,Xi

[ 风险声明 (欧洲) ]:
11-36-66-67

[ 危险品运输编码 ]:
UN 1231 3/PG 2

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Prostaglandin F2α methyl ester文献

Determination of 9alpha, 11beta prostaglandin F2 in human urine. combination of solid-phase extraction and radioimmunoassay.

Prostaglandins Leukot. Essent. Fatty Acids 65(5-6) , 271-80, (2001)

This paper describes a new iodine-125 radioimmunoassay of 9alpha ,11beta-PGF2, and its use for the determination of urinary 9alpha,11beta-prostaglandin F2 after a selective one-step solid-phase extrac...

A comparative study of intravesical instillation of 15(s) 15 Me alpha and alum in the management of persistent hematuria of vesical origin.

Int. J. Clin. Pharmacol. Ther. Toxicol. 30(1) , 7-12, (1992)

A prospective randomized, controlled study was done to compare the efficacy and safety of 15(s) 15 Me PGF2 alpha intravesical instillation and 1% alum vesical irrigation in the control of vesical hema...

[Role of prostaglandins F and E in regulation of bronchial activity].

Pol. Arch. Med. Wewn. 93 , 179, (1995)

Prostaglandins (PGs) belong to the family of eicosanoids. A main substrate in their biosynthesis is arachidonic acid. Involvement of PGs in regulation of bronchial activity is a complex process and fa...

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