N-二乙基亚硝胺

N-二乙基亚硝胺用途

N-亚硝基二甲胺是一种强致癌的二烷基硝胺。N-亚硝基二甲胺主要存在于烟草烟雾、水、切达奶酪、腌制、油炸食品和许多酒精饮料中。N-亚硝基二甲胺负责与DNA修复/复制相关的核酶的变化。N-亚硝基二甲胺在所有动物中都会导致各种肿瘤。主要靶器官是鼻腔、气管、肺、食道和肝脏。

N-二乙基亚硝胺名称

[ CAS 号 ]:
55-18-5

[ 中文名 ]:
N-亚硝基二乙胺

[ 英文名 ]:
N-Nitrosodiethylamine

[中文别名 ]:

[英文别名 ]:

MFCD00013890
DENA
Nitrosodiethylamine
Diethylnitrosoamine
N,N-Diethylnitrosoamine
Diethylamine,N-nitroso
NDEA
Diethylnitrosamine
EINECS 200-226-1
N-nitroso-diethylamine

N-二乙基亚硝胺生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成

N-二乙基亚硝胺物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
173.9±9.0 °C at 760 mmHg

[ 熔点 ]:
<25℃

[ 分子式 ]:
C₄H₁₀N₂O

[ 分子量 ]:
102.135

[ 闪点 ]:
59.0±18.7 °C

[ 精确质量 ]:
102.079315

[ PSA ]:
32.67000

[ LogP ]:
0.42

[ 外观性状 ]:
黄色液体

[ 蒸汽压 ]:
1.7±0.3 mmHg at 25°C

[ 折射率 ]:
1.442

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents, reducing agents.

N-二乙基亚硝胺MSDS

N-二乙基亚硝胺安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311 + H331-H350-H370

[ 警示性声明 ]:
P201-P260-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T,F

[ 风险声明 (欧洲) ]:
45-22-39/23/24/25-23/24/25-11

[ 安全声明 (欧洲) ]:
S53-S45-S36/37-S16

[ 危险品运输编码 ]:
UN 2810 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
IA3500000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

N-二乙基亚硝胺合成路线

N-二乙基亚硝胺制备

1. 烟草：BU，2。

N-二乙基亚硝胺文献

The Japanese toxicogenomics project: application of toxicogenomics.

Mol. Nutr. Food. Res. 54 , 218-27, (2010)

Biotechnology advances have provided novel methods for the risk assessment of chemicals. The application of microarray technologies to toxicology, known as toxicogenomics, is becoming an accepted appr...

Novel study on N-nitrosamines as risk factors of cardiovascular diseases.

Biomed Res. Int. 2014 , 817019, (2014)

Millions of people are exposed daily to N-nitrosamines from different environmental sources. The present study aims at investigating the role of N-nitrosamines in the alteration of homocysteine, lipid...

Genetic targeting of sprouting angiogenesis using Apln-CreER.

Nat. Commun. 6 , 6020, (2015)

Under pathophysiological conditions in adults, endothelial cells (ECs) sprout from pre-existing blood vessels to form new ones by a process termed angiogenesis. During embryonic development, Apelin (A...

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