替瑞酰胺

替瑞酰胺用途

Tiropramide 是一种解痉剂,在肝胆道和泌尿道痉挛性疼痛中发挥重要作用。

替瑞酰胺名称

[ CAS 号 ]:
55837-29-1

[ 中文名 ]:
替瑞酰胺

[ 英文名 ]:
Tiropramide

[英文别名 ]:

替瑞酰胺生物活性

[ 描述 ]:

Tiropramide 是一种解痉剂,在肝胆道和泌尿道痉挛性疼痛中发挥重要作用。

[ 相关类别 ]:

研究领域 >> 其他
信号通路 >> 其他 >> 其他

[参考文献]

[1]. Soo Kyoung Baek, et al. Semi-micro high-performance liquid chromatographic analysis of tiropramide in human plasma using column-switching. J Pharm Biomed Anal. 2003 Feb 5;31(1):185-9.  

替瑞酰胺物理化学性质

[ 密度 ]:
1.06g/cm3

[ 沸点 ]:
655ºC at 760 mmHg

[ 分子式 ]:
C28H41N3O3

[ 分子量 ]:
467.64300

[ 闪点 ]:
349.9ºC

[ 精确质量 ]:
467.31500

[ PSA ]:
61.88000

[ LogP ]:
4.78780

[ 折射率 ]:
1.541

替瑞酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DA8325600
CHEMICAL NAME :
Benzenepropanamide, alpha-(benzoylamino)-4-(2-(diethylamino)ethoxy)-N,N-d ipropyl-, (+-)-
CAS REGISTRY NUMBER :
55837-29-1
LAST UPDATED :
199612
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C28-H41-N3-O3
MOLECULAR WEIGHT :
467.72

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,413,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,413,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
430 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,413,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
33900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4004008
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
550 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,413,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,413,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
245 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,413,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
40500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,413,1982

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