55837-29-1

• 常用中文名：替瑞酰胺
• 常用英文名：Tiropramide
• CAS号：55837-29-1
• 分子式：C₂₈H₄₁N₃O₃
• 分子量：467.64300
• 相关类别： 研究领域 其他
• 发布时间：2018-08-31 18:37:33
• 更新时间：2024-01-03 11:08:03
• Tiropramide 是一种解痉剂,在肝胆道和泌尿道痉挛性疼痛中发挥重要作用。

名称

• 中文名: 替瑞酰胺
• 英文名: N-[3-[4-[2-(diethylamino)ethoxy]phenyl]-1-(dipropylamino)-1-oxopropan-2-yl]benzamide
• 英文别名: Tiropramide; CR-605; Maiorad

物化性质

• 密度: 1.06g/cm3
• 沸点: 655ºC at 760 mmHg
• 分子式: C₂₈H₄₁N₃O₃
• 分子量: 467.64300
• 闪点: 349.9ºC
• 精确质量: 467.31500
• PSA: 61.88000
• LogP: 4.78780
• 折射率: 1.541

生物活性

• 描述: Tiropramide 是一种解痉剂,在肝胆道和泌尿道痉挛性疼痛中发挥重要作用。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Soo Kyoung Baek, et al. Semi-micro high-performance liquid chromatographic analysis of tiropramide in human plasma using column-switching. J Pharm Biomed Anal. 2003 Feb 5;31(1):185-9.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DA8325600 CHEMICAL NAME : Benzenepropanamide, alpha-(benzoylamino)-4-(2-(diethylamino)ethoxy)-N,N-d ipropyl-, (+-)- CAS REGISTRY NUMBER : 55837-29-1 LAST UPDATED : 199612 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C28-H41-N3-O3 MOLECULAR WEIGHT : 467.72 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,413,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 140 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,413,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 430 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,413,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 33900 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4004008 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 550 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,413,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 120 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,413,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 245 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,413,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 40500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,413,1982

合成路线

14325-35-0 ~% 55837-29-1

文献：FR2259592DE2503992 , ; Chem.Abstr., , vol. 83, # 193728

60-18-4 ~% 55837-29-1

文献：FR2259592DE2503992 , ; Chem.Abstr., , vol. 83, # 193728

57227-08-4 ~% 55837-29-1

文献：FR2259592DE2503992 , ; Chem.Abstr., , vol. 83, # 193728

57227-09-5 100-35-6 ~% 55837-29-1

文献：FR2259592DE2503992 , ; Chem.Abstr., , vol. 83, # 193728

上下游产品

上游产品  5
14325-35-0 60-18-4 57227-08-4 57227-09-5
100-35-6
下游产品  0