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4-羟基雌二醇

4-羟基雌二醇用途

4-羟基雌二醇(4-羟基-17β-雌二醇)是雌二醇(HY-B0141)的内源性代谢产物。4-羟基雌二醇具有致癌作用,在乳腺上皮细胞中具有诱变活性。4-羟基雌二醇以竞争方式抑制雌二醇与雌激素受体的结合,Ki为0.48 nM[1][2]。

4-羟基雌二醇名称

[ CAS 号 ]:
5976-61-4

[ 中文名 ]:
4-羟雌二醇

[ 英文名 ]:
4-hydroxyestradiol

[中文别名 ]:

4-羟基雌二醇

[英文别名 ]:

4-Hydroxy-17β-estradiol
MFCD00063335
4-HYDROXYESTRADIOL
4-hydroxy-17beta-estradiol

4-羟基雌二醇生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

[参考文献]

[1]. Fernandez SV, et al. Estradiol and its metabolites 4-hydroxyestradiol and 2-hydroxyestradiol induce mutations in human breast epithelial cells. Int J Cancer. 2006 Apr 15;118(8):1862-8. doi: 10.1002/ijc.21590.

[2]. Van Aswegen CH, et al. Binding of 2-hydroxyestradiol and 4-hydroxyestradiol to estrogen receptors from human breast cancers. J Steroid Biochem. 1989 Apr;32(4):485-92.

4-羟基雌二醇物理化学性质

[ 密度 ]:
1.248g/cm3

[ 沸点 ]:
468.6ºC at 760 mmHg

[ 熔点 ]:
>210ºC (dec.)

[ 分子式 ]:
C₁₈H₂₄O₃

[ 分子量 ]:
288.38100

[ 闪点 ]:
220.6ºC

[ 精确质量 ]:
288.17300

[ PSA ]:
60.69000

[ LogP ]:
3.31480

[ 外观性状 ]:
黄色至浅棕色固体

[ 折射率 ]:
1.622

[ 储存条件 ]:
−20°C

4-羟基雌二醇MSDS

4-羟基雌二醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KG7676000

CHEMICAL NAME :: Estra-1,3,5(10)-triene-3,4,17-beta-triol

CAS REGISTRY NUMBER :: 5976-61-4

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C18-H24-O3

MOLECULAR WEIGHT :: 288.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 900 mg/kg/90D-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1280 ng/kg

SEX/DURATION :: male 8 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - other effects on male Endocrine - androgenic

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 10 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

MUTATION DATA

TEST SYSTEM :: Rodent - hamster

DOSE/DURATION :: 14 mg/kg/7D (Continuous)

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 15,997,1994

4-羟基雌二醇安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H351

[ 警示性声明 ]:
P281

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
40

[ 安全声明 (欧洲) ]:
S22;S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
KG7676000

4-羟基雌二醇合成路线

4-羟基雌二醇上下游产品

4-羟基雌二醇上游产品

4-羟基雌二醇下游产品

4-羟基雌二醇文献

Leptin induces CYP1B1 expression in MCF-7 cells through ligand-independent activation of the ERα pathway.

Toxicol. Appl. Pharmacol. 277(1) , 39-48, (2014)

Leptin, a hormone with multiple biological actions, is produced predominantly by adipose tissue. Among its functions, leptin can stimulate tumour cell growth. Oestrogen receptor α (ERα), which plays a...

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