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邻乙酰氨基酚

邻乙酰氨基酚用途

【用途一】
用于有机合成，制药工业，也用作过氧化氢的稳定剂
【用途二】
用于有机合成，制药工业（抗肿瘤新药嘧啶苯芥的中间体），也用作过氧化氢的稳定剂。

邻乙酰氨基酚名称

[ CAS 号 ]:
614-80-2

[ 中文名 ]:
邻乙酰氨基酚

[ 英文名 ]:
acetoaminophenol

[中文别名 ]:

[英文别名 ]:

2-acetamidophenol
o-(Acetylamino)phenol
EINECS 210-396-9
2-hydroxyacetanilide
2-Acetamino
2-acetamido-pheno
N-(2-Hydroxyphenyl)acetamide
o-Acetamidophenol
2-acetaminophenol
MFCD00002181

邻乙酰氨基酚生物活性

[ 描述 ]:

2-Acetamidophenol (Orthocetamol) 是 Paracetamol (4-acetamidophenol) 的邻位区域异构体。2-Acetamidophenol 是一种有前途的止痛药和抗关节炎药。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Andrusenko I, et al. The Crystal Structure of Orthocetamol Solved by 3D Electron Diffraction. Angew Chem Int Ed Engl. 2019 Aug 5;58(32):10919-10922.

邻乙酰氨基酚物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
343.1±25.0 °C at 760 mmHg

[ 熔点 ]:
205-210 °C(lit.)

[ 分子式 ]:
C₈H₉NO₂

[ 分子量 ]:
151.163

[ 闪点 ]:
161.3±23.2 °C

[ 精确质量 ]:
151.063324

[ PSA ]:
49.33000

[ LogP ]:
0.72

[ 外观性状 ]:
淡棕色粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.619

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, chloroformates, acids, acid chlorides, acid anhydrides.

邻乙酰氨基酚MSDS

邻乙酰氨基酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AE4025000

CHEMICAL NAME :: Acetanilide, 2'-hydroxy-

CAS REGISTRY NUMBER :: 614-80-2

BEILSTEIN REFERENCE NO. :: 0607592

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C8-H9-N-O2

MOLECULAR WEIGHT :: 151.18

WISWESSER LINE NOTATION :: QR BMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 1 mmol/L

REFERENCE :: MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,51,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7933 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 198 (estimated) No. of Female Employees: 151 (estimated)

邻乙酰氨基酚安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
2811

[ WGK德国 ]:
3

[ RTECS号 ]:
AE4025000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
29242995

邻乙酰氨基酚合成路线

邻乙酰氨基酚上下游产品

邻乙酰氨基酚上游产品

邻乙酰氨基酚下游产品

邻乙酰氨基酚制备

合成方法：将邻氨基酚、乙酸及乙酐混合（即有结晶出现），然后直接在火上加热至全部溶解，停止加热，冷却，用水冲稀，析出结晶滤干，以70～80℃的乙醇重结晶而得成品。

邻乙酰氨基酚海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

邻乙酰氨基酚文献

Fabrication of bimetallic Cu/Au nanotubes and their sensitive, selective, reproducible and reusable electrochemical sensing of glucose.

Nanoscale 7 , 11190-8, (2015)

Herein, we report a facile two-step approach to produce gold-incorporated copper (Cu/Au) nanostructures through controlled disproportionation of the Cu(+)-oleylamine complex at 220 °C to form copper n...

Highly exposed Pt nanoparticles supported on porous graphene for electrochemical detection of hydrogen peroxide in living cells.

Biosens. Bioelectron. 74 , 71-7, (2015)

In this study, we developed a novel biosensor based on highly exposed Pt nanoparticles (Pt NPs) decorated porous graphene (PG) for the reliable detection of extracellular hydrogen peroxide (H2O2) rele...

The postprandial plasma rye fingerprint includes benzoxazinoid-derived phenylacetamide sulfates.

J. Nutr. 144(7) , 1016-22, (2014)

The bioavailability of whole-grain rye-derived phytochemicals has not yet been comprehensively characterized, and different baking and manufacturing processes can modulate the phytochemical compositio...

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