2,2-双[4-(4-氨基苯氧基苯)]六氟丙烷

2,2-双[4-(4-氨基苯氧基苯)]六氟丙烷用途

GI-530159 是选择性的 TREK1 (K2P2.1) 和 TREK2 (K2P10.1) 通道的开放剂,对 TREK1 的EC50 为 0.76 μM。GI-530159 显示了 TREK1/2 对 TRAAK,TASK3 和其他钾离子通道的选择性。GI-530159 降低大鼠背根神经节神经元兴奋性。

2,2-双[4-(4-氨基苯氧基苯)]六氟丙烷名称

[ CAS 号 ]:
69563-88-8

[ 中文名 ]:
2,2-双[4-(4-氨基苯氧基)苯基]-1,1,1,3,3,3-六氟丙烷

[ 英文名 ]:
GI-530159

[中文别名 ]:

[英文别名 ]:

2,2-bis(4-[4-aminophenoxy]phenyl)hexafluoropropane
2,2-bis[4-(p-aminophenoxy)phenyl]hexafluoropropane
HFBAPP
MFCD00015723
isbenzenamine
2,2'-BIS[4-(4-AMINOPHENOXY)PHENY]HEXAFLUOROPROPANE
BAPOFP
BIS-AF-A
4-BDAF
leneoxy))bis

2,2-双[4-(4-氨基苯氧基苯)]六氟丙烷生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> 跨膜转运 >> 钾通道

[参考文献]

[1]. Loucif AJC, et al. GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P ) channel opener, reduces rat dorsal root ganglion neuron excitability. Br J Pharmacol. 2018;175(12):2272-2283.

2,2-双[4-(4-氨基苯氧基苯)]六氟丙烷物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
544.8±50.0 °C at 760 mmHg

[ 熔点 ]:
159-163 °C(lit.)

[ 分子式 ]:
C₂₇H₂₀F₆N₂O₂

[ 分子量 ]:
518.450

[ 闪点 ]:
283.3±30.1 °C

[ 精确质量 ]:
518.142883

[ PSA ]:
70.50000

[ LogP ]:
4.57

[ 外观性状 ]:
白色晶体

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.579

[ 储存条件 ]:
室温

2,2-双[4-(4-氨基苯氧基苯)]六氟丙烷MSDS

详细MSDS(安全技术说明书)

2,2-双[4-(4-氨基苯氧基苯)]六氟丙烷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CY1213000

CHEMICAL NAME :: Benzenamine, 4,4'-((2,2,2-trifluoro-1-(trifluoromethyl)ethylidene) bis(4,1-phenyleneoxy) )bis-

CAS REGISTRY NUMBER :: 69563-88-8

LAST UPDATED :: 199806

DATA ITEMS CITED :: 5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0529936-1 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1340 mg/kg

TOXIC EFFECTS :: Liver - other changes

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0529936-1

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0529936-1 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 280 mg/kg/28D-I

TOXIC EFFECTS :: Liver - fatty liver degeneration Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0529936-1

2,2-双[4-(4-氨基苯氧基苯)]六氟丙烷安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
CY1213000

[ 海关编码 ]:
2922299090

2,2-双[4-(4-氨基苯氧基苯)]六氟丙烷海关

[ 海关编码 ]: 2922299090

[ 中文概述 ]:
2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%