红海海绵素 A

红海海绵素 A用途

Latrunculin A (LAT-A) 是从红海海绵 Latrunculia magnifica 中得到的一种毒素,能够与肌动蛋白 (actin) 单体结合,抑制肌动蛋白聚集,对 ATP-actin,ADP-Pi-actin,ADP-actin 和 G-actin 的 Kd 值分别为 0.1,0.4,4.7 μM 和 0.19 μM。

红海海绵素 A名称

[ CAS 号 ]:
76343-93-6

[ 中文名 ]:
红海海绵素 A

[ 英文名 ]:
Latrunculin A

[英文别名 ]:

latrunculin-A
Latrunculin A
latruculin A
latrunculin A (incomplete stereochemistry)
LAT-A

红海海绵素 A生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞骨架 >> Arp2/3复合物

研究领域 >> 其他

[ 靶点 ]

Kd: 0.1 μM (ATP-actin), 0.4 μM (ADP-Pi-actin), 4.7 μM (ADP-actin)[2], 0.19 μM (G-actin)[2]

[参考文献]

[1]. Fujiwara I, et al. Latrunculin A Accelerates Actin Filament Depolymerization in Addition to Sequestering Actin Monomers. Curr Biol. 2018 Oct 8;28(19):3183-3192.e2.

[2]. Coué M, et al. Inhibition of actin polymerization by latrunculin A. FEBS Lett. 1987 Mar 23;213(2):316-8.

红海海绵素 A物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 分子式 ]:
C₂₂H₃₁NO₅S

[ 分子量 ]:
421.550

[ 精确质量 ]:
421.192291

[ PSA ]:
110.16000

[ LogP ]:
4.14

[ 外观性状 ]:
蜡质固体

[ 折射率 ]:
1.533

[ 储存条件 ]:
-20℃

红海海绵素 AMSDS

红海海绵素 A安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

红海海绵素 A合成路线

红海海绵素 A上下游产品

红海海绵素 A上游产品

红海海绵素 A下游产品

红海海绵素 A文献

Inhibitory mechanism of FAT4 gene expression in response to actin dynamics during Src-induced carcinogenesis.

PLoS ONE 10(2) , e0118336, (2015)

Oncogenic transformation is characterized by morphological changes resulting from alterations in actin dynamics and adhesive activities. Emerging evidence suggests that the protocadherin FAT4 acts as ...

Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function.

Skelet. Muscle 5 , 4, (2015)

Ca(2+) influx through CaV1.1 is not required for skeletal muscle excitation-contraction coupling, but whether Ca(2+) permeation through CaV1.1 during sustained muscle activity plays a functional role ...

Activation of the pleiotropic drug resistance pathway can promote mitochondrial DNA retention by fusion-defective mitochondria in Saccharomyces cerevisiae.

G3 (Bethesda) 4(7) , 1247-58, (2014)

Genetic and microscopic approaches using Saccharomyces cerevisiae have identified many proteins that play a role in mitochondrial dynamics, but it is possible that other proteins and pathways that pla...

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