198904-86-8

• 常用中文名：2-[(2S,3S)-3-[[(叔丁氧基)羰基]氨基]-2-羟基-4-苯基丁基]-2-[[4-(2-吡啶基)苯基]甲基]肼羧酸叔丁酯
• 常用英文名：Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir
• CAS号：198904-86-8
• 分子式：C₃₂H₄₂N₄O₅
• 分子量：562.700
• 相关类别： 医药中间体 杂环化合物 吡啶类化合物 羟基吡啶
• 发布时间：2018-07-24 18:48:08
• 更新时间：2026-07-02 08:23:38

名称

• 中文名: 1-[4-(吡啶-2-基)苯基]-5(S)-2,5-双 [(叔丁基氧基羰基)–氨基]-4(S)-羟基l-6-苯基-2-氮杂己烷
• 英文名: 1-[4-(pyridin-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
• 中文别名: 1-[4-(吡啶-2-基)苯基]-5(S)-2,5-双 [(叔丁基氧基羰基)–氨基]-4(S)-羟基L-6-苯基-2-氮杂己烷; 1-[4-(吡啶-2-基)苯]-5(S)-2,5-双 [(叔丁氧羰基)-氨基]-4(S)-羟基-6-苯-2-氮杂己烷; 阿扎那韦杂质4; 阿扎那韦中间体,2-[(2S,3S)-3-[[(叔丁氧基)羰基]氨 基]-2-羟基-4-苯基丁基]-2-[[4-(2-吡 啶基)苯基]甲基]肼羧酸叔丁酯; 阿扎那韦杂质J; 2-(2S,3S)-3-(叔丁氧羰基)氨基)-2-羟基-4-苯基丁基)-2-(4-(吡啶-2-基)苄基)肼甲酸叔丁酯 (阿扎那韦杂质); 阿扎那韦中间体4; 硫酸阿扎那韦杂质J; 阿扎那韦中间体4/DES-N-(METHOXYCBONYL)-L-TERT-LEUCINE BIS-BOC ATAZANAVIR; 阿扎那韦杂质J(阿扎那韦二叔丁基类似物); 硫酸阿扎那韦中间体; 阿扎那韦硫酸盐杂质1
• 英文别名: 2-(4-(pyridin-2-yl); 2-[(2S,3S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl]-2-[[4-(2-pyridinyl)phenyl]methyl]hydrazinecboxylic acid tert-butyl ester; 2-[(2S,3S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl] -2-[[4-(2-pyridinyl)phenyl]methyl]hydrazinecboxylic Acid 1,1-Dimethylethyl Ester; tert-Butyl 2-((2S,3S); 1-[4-(pyridin-2-yl)-phenyl]-4(S)-hydroxy-5(S)-2,5-bis[(tert-butoxycarbonyl)amino]-6-phenyl-2-azahexane; AtazanavirSulfateInterMediates-01; Atazanavir Impurity 16; 1-[4-(Pyridin-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycbonyl)-amino]-4(S)-hydroxyl-6-phenyl-2-azahexane; 2-Methyl-2-propanyl 2-[(2S,3S)-2-hydroxy-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-4-phenylbutyl]-2-[4-(2-pyridinyl)benzyl]hydrazinecarboxylate; Des-N-(methoxycbonyl)-L-tert-leucine Bis-Boc Atazanavir; Hydrazinecarboxylic acid, 2-[(2S,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl]-2-[[4-(2-pyridinyl)phenyl]methyl]-, 1,1-dimethylethyl ester; 2-[(2S,3S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenyl-butyl]-2-[[4-(2-pyridinyl)phenyl]methyl]hydrazinecboxyli; 1-[4-(pyridine-2-yl)-phenyl]-4(S)-hydroxy-5(S)-2,5-bis[(tert-butoxycarbonyl)amino]-6-phenyl-2-azahexane; Azanavir Impurity J; tert-Butyl 2-{(2S,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}-2-[4-(pyridin-2-yl)benzyl]hydrazinecarboxylate; 2-[(2S,3S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl] -2-[[4-(2-pyridiny; Des-N-(methoxycbonyl)-L-tert-leucine Bis-Boc Atazanavir ISO 9001：2015 REACH; 1-(4-(pyridin-2-yl)phenyl)-5(S)-2,5-bis((tert-butyloxy-carbonyl); tert-Butyl N-[(1S,2S)-1-Benzyl-3-[(tert-butoxycbonylamino)-[[4-(2-pyridyl)phenyl]methyl]amino]-2-h; 1-[4-(Pyridin-2-yl)phenyl]-5-(s)-2,5-bis[(tert-butylox ycbonyl)-amino]-4(s)-hydroxyl-6-phenyl-2-azahex; tert-butyl 2-((2S,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinecarboxylate; Hydrazinecboxylic acid, 2-[(2S,3S)-3-[[(1,1; N-tert-butoxycarbonylglycine N-methyl-N-methoxyamide; tert-butyl 2-((2S,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazincarboxylate; 2-[(2S,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl]-2-[[4-(2-pyridi; Atazanavir Impurity J (Atazanavir Di-tert-butyl Analog); Atazanavir Intermediate 4; tert-Butyl 2-[(2S,3S)-3-[(tert-butoxycbonyl)amino]-2-hydroxy-4-phenylbutyl]-2-[[4-(pyridin-2- yl)phenyl]methyl]hydrazine-1-cboxylate; Tert-butyl 2-{(2S,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}-2-[4-(2-pyridinyl)benzyl]hydrazinecarboxylate; tert-Butyl N-[(1S,2S)-1-Benzyl-3-[(tert-butoxycbonylamino)-[[4-(2-pyridyl)phenyl]methyl]amino]-2-hydroxy-propyl]cbamate; phenylbutyl]-2-[[4-(2-pyridinyl)phenyl]methyl]-,1,1-dimethylethyl ester; dimethylethoxy)carbonyl]amino]-2-hydroxy-4; tert-Butyl 2-((2S,3S)-3-((tert-butoxycbonyl)amino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinecboxylate; 1-[4-(pyridin-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane; tert-Butyl 2-((2S,3S)-3-((tert-butoxycbonyl)amino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinecboxylate (Atazanavir Impurity); Atazanavir Impurity 4; 2-hydroxy-4-phenylbutyl); Hydrazinecboxylic acid, 2-[(2S,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl]-2-[[4-(2-pyridinyl)phenyl]methyl]-, 1,1-dimethylethyl ester; tert-Butyl 2-[(2S,3S)-3-(tert-butoxyformamido)-2-hydroxy-4-phenylbutyl]-2-[[4-(pyridin-2-yl)phenyl]methyl]hydrazine-1-cboxylate; Azanavir sulfate impurity 1; 1-[4-(Pyridin-2Yl)Phenyl]-5(S)-2,5-Bis[Tert-Butyloxycbonyl)Amino]-4(S)-Hydroxyl-6-Phenyl-2-Azhexane; 2-[(2S,3S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl]-2; 1-[4-(Pyridin-2-yl)phenyl]-5(S)-2,5-bis[(tert-butoxycbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane; N-Boc-glycine N'-methoxy-N'-methylamide; 1-[4-(pyridin-2-yl)phenyl]-(5S)-2,5-bis[(tert-butoxycarbonyl)amino]-(4S)-hydroxy-6-phenyl-2-azahexane; Atazanavir Sulfate Impurity J; Tert-butyl 2-{(2S,3S)-3-[(tert-butoxycbonyl)amino]-2-hydroxy-4-phenylbutyl}-2-[4-(2-pyridinyl)benzyl]hydrazinecboxylate

物化性质

• 密度: 1.2±0.1 g/cm3
• 熔点: 184 °C
• 分子式: C₃₂H₄₂N₄O₅
• 分子量: 562.700
• 精确质量: 562.315491
• PSA: 113.02000
• LogP: 6.24
• 外观性状: 灰白色
• 折射率: 1.568
• 储存条件: 2-8°C

安全

• 危害码 (欧洲): Xn

合成路线

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