1879-77-2

• 常用中文名：9Α-氟-16Β-甲基孕甾-1,4-二烯-11Β,17Α-二醇-3,20-二酮
• 常用英文名：21-Deoxy Betamethasone
• CAS号：1879-77-2
• 分子式：C₂₂H₂₉FO₄
• 分子量：376.462
• 发布时间：2016-11-26 15:59:28
• 更新时间：2026-08-14 19:04:31

名称

• 中文名: 9Α-氟-16Β-甲基孕甾-1,4-二烯-11Β,17Α-二醇-3,20-二酮
• 英文名: 16β-methyl-9α-fluoro-11β,17α-dihydroxy-1,4-pregnadiene-3,20-dione
• 中文别名: 多倍他索杂质; 多西倍他索; 戊酸倍他米松杂质B; 多倍他索; 21-脱氧倍他米松; (11β,16β)-9-氟-11,17-二羟基-16-甲基孕甾-1,4-二烯-3,20-二酮; 倍他米松VALERATE 杂质B(21脱氧倍他米SONE); 倍他米松戊酸酯杂质B
• 英文别名: 9-Fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione; 16β-Methyl-11β,17-dihydroxy-9-fluoro-5α-pregnane-1,4-diene-3,20-dione; (8S,9R,10S,11S,13S,14S,16S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one; βmethasone Valerate Impurity B; Betamethasone Valerate Impurity B; (11β,16β)-9-Fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione; 9-Fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione; Betamethasone Valerate Impurity B (21-Deoxy Betamethasone); 9-Fluoro-16-methylpregna-1,4-diene-11,17-diol-3,20-dione; Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-, (11β,16β); Betamethasone Valerate impurity 1/Betamethasone Valerate Impurity B/Doxybetasol/21-Deoxy Betamethasone; doxibetasol; gr 2/443; (8S,9R,10S,11S,13S,14S,16S,17R)-17-ethanoyl-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one; Doxybetasol; Doxibetasol [INN]; 9-Fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione; 1,4-pregnadien-9alpha-fluoro-16alpha-methyl-11beta,17,diol-3,20-dione

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 527.1±50.0 °C at 760 mmHg
• 分子式: C₂₂H₂₉FO₄
• 分子量: 376.462
• 闪点: 272.6±30.1 °C
• 精确质量: 376.204987
• PSA: 74.60000
• LogP: 2.02
• 蒸汽压: 0.0±3.1 mmHg at 25°C
• 折射率: 1.574

合成路线

37413-99-3 ~83% 1879-77-2

文献：Kongkathip, Ngampong; Kongkathip, Boonsong; Noimai, Naratitt Synthetic Communications, 2006 ,  vol. 36,  # 7  p. 865 - 874

14135-32-1 ~% 1879-77-2

文献：Kongkathip, Ngampong; Kongkathip, Boonsong; Noimai, Naratitt Synthetic Communications, 2006 ,  vol. 36,  # 7  p. 865 - 874

113926-56-0 ~% 1879-77-2

文献：Kongkathip, Ngampong; Kongkathip, Boonsong; Noimai, Naratitt Synthetic Communications, 2006 ,  vol. 36,  # 7  p. 865 - 874

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