987-24-6

• 常用中文名：醋酸倍他米松
• 常用英文名：Betamethasone Acetate
• CAS号：987-24-6
• 分子式：C₂₄H₃₁FO₆
• 分子量：434.498
• 相关类别： 原料药 激素及调节内分泌功能类药 肾上腺皮质激素类药
• 发布时间：2018-07-28 23:17:12
• 更新时间：2024-01-03 08:12:21
• Betamethasone acetate 是一种糖皮质激素。Betamethasone acetate 诱导早产羊的胎儿肺成熟。

名称

• 中文名: 醋酸倍氟美松
• 英文名: betamethasone acetate
• 中文别名: 20-二酮-21-醋酸酯; 醋酸倍他米松; 16beta-甲基-11beta,17alpha,21-三羟基-9alpha-氟-孕甾-1,4-二烯-3,20-二酮-21-醋酸酯; 9Α-氟-16Β-甲基-11Β,17Α,21-三羟基-1,4孕二烯-3,20-二酮21-醋酸; 醋酸倍他米松杂质
• 英文别名: Betamethasone acetate; MFCD00867462; (11β,16β)-9-Fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl acetate; Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(acetyloxy)-, (11β,16β)-; Betafluorene; Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-16-methyl-, (11β,16β)-; UNII-TI05AO53L7; 2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl acetate; 9-Fluoro-11b,17,21-trihydroxy-16b-methylpregna-1,4-diene-3,20-dione 21-Acetate; EINECS 213-578-6; Betamethasone 21-acetate

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 579.4±50.0 °C at 760 mmHg
• 熔点: 200-220°C (dec.)
• 分子式: C₂₄H₃₁FO₆
• 分子量: 434.498
• 闪点: 304.2±30.1 °C
• 精确质量: 434.210480
• PSA: 100.90000
• LogP: 2.96
• 蒸汽压: 0.0±3.6 mmHg at 25°C
• 折射率: 1.571
• 储存条件: Refrigerator
• 分子结构:

  1、 摩尔折射率：109.82

  2、 摩尔体积（m³/mol）：334.0

  3、 等张比容（90.2K）：900.9

  4、 表面张力（dyne/cm）：52.9

  5、 极化率（10 ^-24cm ³）：43.53

• 计算化学:

  1、 疏水参数计算参考值（XlogP）：2.8

  2、 氢键供体数量：2

  3、 氢键受体数量：7

  4、 可旋转化学键数量：4

  5、 互变异构体数量：6

  6、 拓扑分子极性表面积（TPSA）：101

  7、 重原子数量：31

  8、 表面电荷：0

  9、 复杂度：910

  10、 同位素原子数量：0

  11、 确定原子立构中心数量：8

  12、 不确定原子立构中心数量：0

  13、 确定化学键立构中心数量：0

  14、 不确定化学键立构中心数量：0

  15、 共价键单元数量：1

• 更多:

  1. 性状：未确定。

  2. 密度（g/mL,25/4℃）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：200-220°C

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：未确定

生物活性

• 描述: Betamethasone acetate 是一种糖皮质激素。Betamethasone acetate 诱导早产羊的胎儿肺成熟。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Schmidt AF, et al. Low-dose betamethasone-acetate for fetal lung maturation in preterm sheep. Am J Obstet Gynecol. 2018 Jan;218(1):132.e1-132.e9.

MSDS

Section 1. Chemical Product and Company Identification Betamethasone acetateCatalog YY1144, BE182 Common Name/ Number(s). Trade Name CAS#987-24-6 Manufacturer RTECSNot available. SPECTRUM QUALITY PRODUCTS INC. TSCATSCA 8(b) inventory: No products were found. Commercial Name(s)Not available. CI# Not available. Synonym9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione IN CASE OF EMERGENCY acetate Chemical NameNot available. Not available.CALL (310) 516-8000 Chemical Family Chemical FormulaC24H31FO6 SPECTRUM QUALITY PRODUCTS INC. Section 2.Composition and Information on Ingredients Exposure Limits TWA (mg/m3)STEL (mg/m3) CEIL (mg/m3) NameCAS #% by Weight 1) Betamethasone acetate987-24-6100 Toxicological DataNot applicable. on Ingredients Section 3. Hazards Identification Potential Acute Health Effects Hazardous in case of ingestion. Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation. Potential Chronic HealthHazardous in case of ingestion. EffectsSlightly hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation. CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. Betamethasone acetate Section 4. First Aid Measures Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention if irritation occurs. Skin ContactWash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Serious Skin ContactNot available. InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious InhalationNot available. IngestionDo NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Serious IngestionNot available. Section 5. Fire and Explosion Data Flammability of the Product May be combustible at high temperature. Auto-Ignition Temperature Not available. Flash PointsNot available. Flammable LimitsNot available. Products of CombustionThese products are carbon oxides (CO, CO2), halogenated compounds. Fire Hazards in Presence of Not available. Various Substances Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in presence of static discharge: Not available. of Various Substances SMALL FIRE: Use DRY chemical powder. Fire Fighting Media and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet. Not available. Special Remarks on Fire Hazards Special Remarks on Explosion Not available. Hazards Section 6. Accidental Release Measures Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Large SpillUse a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Betamethasone acetate Section 7. Handling and Storage PrecautionsKeep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not breathe dust. StorageKeep container tightly closed. Keep container in a cool, well-ventilated area. Section 8. Exposure Controls/Personal Protection Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal Protection Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used a Large Spillto avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure LimitsNot available. Section 9. Physical and Chemical Properties Physical state and appearance Solid. (Powdered solid.)OdorNot available. TasteNot available. Molecular Weight434.5 g/mole ColorNot available. pH (1% soln/water)Not applicable. Boiling PointDecomposes. Melting Point206.5°C (403.7°F) Critical TemperatureNot available. Not available. Specific Gravity Vapor PressureNot applicable. Vapor DensityNot available. VolatilityNot available. Odor ThresholdNot available. Not available. Water/Oil Dist. Coeff. Ionicity (in Water)Not available. See solubility in water, methanol. Dispersion Properties SolubilityPartially soluble in methanol. Insoluble in cold water. Section 10. Stability and Reactivity Data StabilityThe product is stable. Instability TemperatureNot available. Conditions of InstabilityNot available. Incompatibility with variousNot available. substances CorrosivityNon-corrosive in presence of glass. Betamethasone acetate Not available. Special Remarks on Reactivity Not available. Special Remarks on Corrosivity PolymerizationWill not occur. Section 11. Toxicological Information Routes of EntryIngestion. Toxicity to AnimalsLD50: Not available. LC50: Not available. Chronic Effects on Humans Not available. Other Toxic Effects on Hazardous in case of ingestion. HumansSlightly hazardous in case of skin contact (irritant), of inhalation. Special Remarks on Not available. Toxicity to Animals Special Remarks onNot available. Chronic Effects on Humans Special Remarks on otherNot available. Toxic Effects on Humans Section 12. Ecological Information EcotoxicityNot available. Not available. BOD5 and COD Possibly hazardous short term degradation products are not likely. However, long term degradation products may Products of Biodegradation arise. Toxicity of the ProductsThe products of degradation are more toxic. of Biodegradation Special Remarks on theNot available. Products of Biodegradation Section 13. Disposal Considerations Waste Disposal Section 14. Transport Information DOT ClassificationNot a DOT controlled material (United States). IdentificationNot applicable. Not applicable. Special Provisions for Transport DOT (Pictograms) Betamethasone acetate Section 15. Other Regulatory Information and Pictograms TSCA 8(b) inventory: No products were found. Federal and State Regulations California Proposition 65 Warnings Other RegulationsNot available. WHMIS (Canada) Not controlled under WHMIS (Canada). Other Classifications DSCL (EEC)This product is not classified according to the EU regulations. Health Hazard HMIS (U.S.A.)1 National Fire Protection 1 Flammability 1 Association (U.S.A.) Fire Hazard 1 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection E WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) TDG (Canada) (Pictograms) ADR (Europe) (Pictograms) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Safety glasses. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 符号: GHS08
• 信号词: Warning
• 危害声明: H351
• 警示性声明: P280
• 危害码 (欧洲): Xn:Harmful
• 风险声明 (欧洲): R40
• 安全声明 (欧洲): S22-S36
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3

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