96036-02-1

• 常用中文名：保护美罗培南
• 常用英文名：Protected meropenem
• CAS号：96036-02-1
• 分子式：C₃₂H₃₅N₅O₁₁S
• 分子量：697.712
• 发布时间：2018-08-17 20:34:27
• 更新时间：2026-07-02 08:40:43

名称

• 中文名: 保护美罗培南
• 英文名: (4-nitrophenyl)methyl 3-[5-(dimethylcarbamoyl)-1-[(4-nitrophenyl)methoxycarbonyl]pyrrolidin-2-yl]sulfanyl-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
• 中文别名: (4R,5S,6S)-3-[[(3S,5S)-5-[(二甲基氨基)甲酰基-1-[[(4-硝基苄基)氧]羰基]-3-吡咯烷基]硫]-6-[(1R)-1-羟乙基]-4-甲基-7-氧代-1-氮杂双环[3.2.0]庚-2-烯-2-羧酸 4-硝基苄基酯; 美罗培南对硝基苄基二酯; 受保护的美罗培南; 美罗培南PA041杂质; 保护的美罗培南; (4R,5S,6S)-3-[[(3S,5S)-5-(二甲基氨基甲酰基)-1-[[(4-硝基苄基)氧基]羰基]-3-吡咯烷基]硫基]-6-[(R)-1-羟基乙基]-4-甲基-7-氧代-1-氮杂双环[3.2.0]庚-2-烯-2-甲酸(4-硝基苄基)酯; (4R,5S,6S)-4-硝基苄基-3-[[(3S,5S)-5-[(二甲基氨基)甲酰基-1-[[(4-硝基苄基)氧]羰基]-3-吡咯烷基]硫]-6-[(1R)-1-羟乙基]-4-甲基-7-氧代-1-氮杂双环[3.2.0]庚-2-烯-2-羧酸酯; PNB保护美罗培南(F12); PNB 保护美罗培南(F12); 美罗培南杂质37
• 英文别名: PROTECTED MEROPENEM; 4-Nitrobenzyl (4R,5S,6S)-3-[[(3S,5S)-5-(Dimethylcbamoyl)-1-[[(4-nitrobenzyl)oxy]carbonyl]-3-pyrrolidinyl]thio]-6-[(R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]ht-2-ene-2-cboxylate; 3-[[5-[(Dimethylamino)carbonyl-Pyrrolidinyl]Thio]-6-(1-Hydroxyethyl)-4-Methyl-7-Oxo-1-Azabicyclo[3.2.0]Ht-2-Ene-2-Cboxylic Acid, (4-Nitrophenyl)Methyl Ester; 3-[[5-[(DIMETHYLAMINO)CBONY PYRROLIDINYL] THIO]-6-(1-HYDROXYETHYL)-4-METHYL-7-OXO-1-AZABICYCLO[3.2.0]HT-2-ENE-2-CBOXYLIC ACID, (4-NITROPHENYL)METHYL ESTER; MeropeneM InterMediates(E-8,MRPM-PNB); (FAVORITES COMPE MEROPENEM INTERMEDIATES WITH; 3-[[5-[dimethylamino(oxo)methyl]-1-[(4-nitrophenyl)methoxy-oxomethyl]-2-pyrrolidinyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (4-nitrophenyl)methyl ester; 5) PROTECTED MEROPENEM; 3-[[5-[(Dimethylamino)Cbonypyrrolidinyl]Thio]-6-(1-Hydroxyethyl)-4-Methyl-7-Oxo-1-Azabicyclo[3.2.0]Ht-2-Ene-2-Cboxylic Acid, (4-Nitrophenyl)Methyl Ester; Meropenem p-nitrobenzyl diester; Meropenem impurity 37; p-nitrobenzyl (4R,5S,6S)-3-<(3S,5S)-5-dimethylaminocarbonyl-1-(p-nitrobenzyloxycarbonyl)pyrrolidin-3-ylthio>-6-<(1R)-1-hydroxyethyl>-4-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-en-2-carboxylate; MFCD08703333; (4R,5S,6S)-p-nitrobenzyl 3-<(3S,5S)-(5-dimethylaminocarbonyl-1-p-nitrobenzyloxycarbonyl)pyrrolidin-3-yl>-6-<(1R)-1-hydroxyethyl>-4-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate; (4R,5S,6S)-4-NITROBENZYL-3-[[(3S,5S)-5-[(DIMETHYLAMINO)carbonyl]-1-[[(4-NITROBENZYL)OXY] carbonyl]-3-PYRROLIDINYL]THIO]-6-[(1R)-1-HYDROXYETHYL]-4-METHYL-7-OXO-1-AZABICYCLO[3,2,0] HT-2-ENE-2-CBOXYLATE; 4-nitrobenzyl (4R,5S,6S)-3-(((3S,5S)-5-[(dimethylamino)carbonyl]-1-[(4-nitrophenoxy)carbonxyl]pyrrolidin-3-yl)thio)-6-[(1R)-1-hydorxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate; PNB protected meropenem (F12); (4-nitrophenyl)methyl 3-[5-(dimethylcbamoyl)-1-[(4-nitrophenyl)methoxycbonyl]pyrrolidin-2-yl]sulfanyl-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]ht-2-ene-2-cboxylate; P-NITROBENZYL(4R,5S,6S)-3-[(3S,5S)-(5-DIMETHYLAMINOCBONYL-1-P-NITROBENZYLOXYCBONYL)-PYRROLIDIN-3-YLSULFANYL]-6-((R)-1-HYDROXY-ETHYL)-4-METHYL-7-OXO-1-AZA-BICYCLO[3.2.0]HT-2ENE-4-CBOXYLATE; 4-nitrobenzyl (5s,6s)-3-[((3s,5s)-5-[(dimethylamino)carbonyl]-1-{[(4-nitrobenzyl)oxy]carbonyl}pyrrolidinyl)sulfanyl]-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]ht-2-ene-2-cboxylate; p-nitrobenzyl (4R,5S,6S)-3-<(3S,5S)-5-dimethylaminocbonyl-1-(p-nitrobenzyloxycbonyl)pyrrolidin-3-ylthio>-6-<(1R)-1-hydroxyethyl>-4-methyl-7-oxo-1-azabicyclo.0>ht-2-en-2-cboxylate; Meropenem Impurity 30; 4-Nitrobenzyl (4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)-1-{[(4-nitrobenzyl)oxy]carbonyl}-3-pyrrolidinyl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate; PROTECTED MEROPENEM, min; 4-nitrobenzyl (4R,5S,6S)-3-[[(3S,5S)-5-[(dimethylamino)carbonyl]-1-[[(4-nitrobenzyl)oxy]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate; (4-nitrophenyl)methyl 3-[5-(dimethylcarbamoyl)-1-[(4-nitrophenyl)methoxycarbonyl]pyrrolidin-2-yl]sulfanyl-6-(1-hydroxyethyl)-4-methyl-7-oxidanylidene-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate; (4R,5S,6S)-(p-nitrobenzyl) 3-[[(3S,5S)-1-(p-nitrobenzyloxycarbonyl)-5-(dimethylaminocarbonyl)-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate; Benzenesulfonylchloride,5-bromo-7-ethoxy; 4-Nitrobenzyl(5S,6S)-3-(((3S,5S)-5-((Dimethylamino) carbonyl)-1(((4Nitrobenzyl)Oxy)carbonyl)Pyrrolidin)Sulfanyl)-6-((1R); p-nitrobenzyl (4R,5S,6S)-3-[[(3S,5S)-1-(p-nitrobenzyloxycarbonyl)-5-(dimethylaminocarbonyl)-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate; 1-Azabicyclo[3.2.0]ht-2-ene-2-cboxylic acid, 3-[[(3S,5S)-5-[(dimethylamino)carbonyl]-1-[[(4-nitrophenyl)methoxy]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-, (4-nitrophenyl)methyl ester, (4R,5S,6S); p-Nitrobenzyl(1R,5S,6S)-2-[(3S,5S)-(5-dimethylaminocbonyl-1-p-nitrobenzyloxycbonyl)pyrrolidin-3-cboxylate

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 900.3±65.0 °C at 760 mmHg
• 熔点: 150-153ºC (dec.)
• 分子式: C₃₂H₃₅N₅O₁₁S
• 分子量: 697.712
• 闪点: 498.3±34.3 °C
• 精确质量: 697.205383
• PSA: 233.63000
• LogP: -0.64
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.673
• 储存条件: 2-8°C，干燥密封

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