59619-81-7

• 常用中文名：依替前列通
• 常用英文名：(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E)-2-[2-(phenoxymethyl)-1,3-dioxolan-2-yl]ethenyl]cyclopentyl]hept-5-enoic acid
• CAS号：59619-81-7
• 分子式：C₂₄H₃₂O₇
• 分子量：432.507
• 发布时间：2018-08-31 14:03:29
• 更新时间：2024-04-05 19:49:59

名称

• 中文名: 依替前列通
• 英文名: (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E)-2-[2-(phenoxymethyl)-1,3-dioxolan-2-yl]ethenyl]cyclopentyl]hept-5-enoic acid
• 中文别名: (5Z)-7-[(1R,2R,3R,5S)-3,5-二羟基-2-[(1E)-2-[2-(苯氧基甲基)-1,3-二氧环戊-2-基]乙烯基]环戊基]-5-庚烯酸; 依替前列酮
• 英文别名: (5Z)-7-[(1R,2R,3R)-3,5-Dihydroxy-2-{(E)-2-[2-(phenoxymethyl)-1,3-dioxolan-2-yl]vinyl}cyclopentyl]-5-heptenoic acid; 15-Deoxy-15,15-ethylenedioxy-16-phenoxy-17,18,19,20-tetranorprostaglandinF2a; Etiprostone [INN-French]; (5Z,13E)-(8R,9S,11R,12R)-9,11-Dihydroxy-15,15-ethylenedioxy-16-phenoxy-17,18,19,20-tetranorprostadienoic Acid; Etiprostonum [INN-Latin]; Etiprostone; Etiprostonum; Etiproston; 5-Heptenoic acid, 7-[(1R,2R,3R)-3,5-dihydroxy-2-[(E)-2-[2-(phenoxymethyl)-1,3-dioxolan-2-yl]ethenyl]cyclopentyl]-, (5Z)-; (5Z)-7-[(1R,2R,3R)-3,5-Dihydroxy-2-{(E)-2-[2-(phenoxymethyl)-1,3-dioxolan-2-yl]vinyl}cyclopentyl]hept-5-enoic acid; (5Z,13E)-(8R,9S,11R,12R)-9,11-dihydroxy-15,15-ethylenedioxy-16-phenoxy-17,18,19,20-tetranor-prostadienoic acid; Etiproston (INN); (5Z)-7-[(1R,2R,3R)-3,5-dihydroxy-2-{(E)-2-[2-(phenoxymethyl)-1,3-dioxolan-2-yl]ethenyl}cyclopentyl]hept-5-enoic acid; [1R-(1a(Z),2b(E),3a,5a)]-7-[3,5-Dihydroxy-2-[2-[2-(phenoxymethyl)-1,3-dioxolan-2-yl]ethenyl]cyclopentyl]-5-heptenoic Acid

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 598.1±50.0 °C at 760 mmHg
• 分子式: C₂₄H₃₂O₇
• 分子量: 432.507
• 闪点: 200.2±23.6 °C
• 精确质量: 432.214813
• PSA: 105.45000
• LogP: 1.66
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.633

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : MJ9671000 CHEMICAL NAME : 5-Heptenoic acid, 7-(3,5-dihydroxy-2-(2-(2-(phenoxymethyl)-1,3-dioxolan -2-yl)ethenyl) cyclopentyl)-, (1R-(1-alpha(Z),2-beta(E),3-alpha,5-alpha))- CAS REGISTRY NUMBER : 59619-81-7 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C24-H32-O7 MOLECULAR WEIGHT : 432.56 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 600 ug/kg SEX/DURATION : female 4-7 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,443,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 25 ug/kg SEX/DURATION : female 29 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - physical REFERENCE : ANIPA8 Animal Production. (Scotish Academic Press Ltd., 33 Montgomery Street, Edinburgh EH7 5JX, UK) V.1- 1959- Volume(issue)/page/year: 49,129,1989