175276-93-4

• 常用中文名：2-(2,4-二氟苯基)噻唑-4-羧酸乙酯
• 常用英文名：Ethyl 2-(2,4-difluorophenyl)thiazole-4-carboxylate
• CAS号：175276-93-4
• 分子式：C₁₂H₉F₂NO₂S
• 分子量：269.26700
• 发布时间：2018-12-30 18:47:56
• 更新时间：2024-01-29 21:37:20
• 下载msds

名称

• 中文名: 2-(2,4-二氟苯基)噻唑-4-羧酸乙酯
• 英文名: Ethyl 2-(2,4-difluorophenyl)thiazole-4-carboxylate
• 中文别名: ETHYL 2-(2,4-DIFLUOROPHENYL)-1,3-THIAZOLE-4-CARBOXYLATE
• 英文别名: MFCD00277200; ethyl 2-(2,4-difluorophenyl)-1,3-thiazole-4-carboxylate

物化性质

• 密度: 1.344g/cm3
• 沸点: 355.9ºC at 760mmHg
• 熔点: 50 °C
• 分子式: C₁₂H₉F₂NO₂S
• 分子量: 269.26700
• 闪点: 169.1ºC
• 精确质量: 269.03200
• PSA: 67.43000
• LogP: 3.26500
• 计算化学:

  1.疏水参数计算参考值（XlogP）:3.4

  2.氢键供体数量:0

  3.氢键受体数量:6

  4.可旋转化学键数量:4

  5.互变异构体数量:无

  6.拓扑分子极性表面积67.4

  7.重原子数量:18

  8.表面电荷:0

  9.复杂度:306

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：未确定

  2. 密度（g/mL, 25 ℃ ）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：50

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC 28 mmHg）：未确定

  7. 折射率：未确定

  8. 闪点（ºF 28mm ）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：未确定

MSDS

Name: Ethyl 2-(2 4-difluorophenyl)-1 3-thiazole-4-carboxylate 97% Material Safety Data Sheet Synonym: CAS: 175276-93-4 Section 1 - Chemical Product MSDS Name:Ethyl 2-(2 4-difluorophenyl)-1 3-thiazole-4-carboxylate 97% Material Safety Data Sheet Synonym: Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 175276-93-4 Ethyl 2-(2,4-difluorophenyl)-1,3-thiaz 97% unlisted Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Not available. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. May be harmful if absorbed through the skin. Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed. Inhalation: May cause respiratory tract irritation. May be harmful if inhaled. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGE Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Storage: Store in a cool, dry place. Store in a tightly closed container. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 175276-93-4: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: brown Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 50 - 52 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C12H9F2NO2S Molecular Weight: 269 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Not available. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Oxidizing agents, reducing agents, bases. Hazardous Decomposition Products: Hydrogen cyanide, nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide, fluorine, hydrogen fluoride gas. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 175276-93-4 unlisted. LD50/LC50: Not available. Carcinogenicity: Ethyl 2-(2,4-difluorophenyl)-1,3-thiazole-4-carboxylate - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA No information available. IMO No information available. RID/ADR No information available. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 175276-93-4: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 175276-93-4 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 175276-93-4 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xi: Irritant;
• 风险声明 (欧洲): 36
• 安全声明 (欧洲): S24/25
• 海关编码: 2934100090

合成路线

70-23-5 175276-92-3 ~99% 175276-93-4

文献：Reiter, Lawrence A.; Linde, Robert G. Patent: US2008/76771 A1, 2008 ; Location in patent: Page/Page column 19 ;

上下游产品

上游产品  2
70-23-5 175276-92-3
下游产品  1
262589-15-1

海关

海关编码	2934100090
中文概述	2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%