133099-11-3

• 常用中文名：(S)-alpha,alpha-二苯-3-吡咯烷乙酰胺
• 常用英文名：2,2-Diphenyl-2-[(3S)-3-pyrrolidinyl]acetamide
• CAS号：133099-11-3
• 分子式：C₁₈H₂₀N₂O
• 分子量：280.364
• 发布时间：2018-12-30 10:02:47
• 更新时间：2024-01-02 21:04:27

名称

• 中文名: (S)-alpha,alpha-二苯-3-吡咯烷乙酰胺
• 英文名: (S)-α,α-Diphenyl-3-pyrrolidineacetamide
• 中文别名: (S)-Α,Α'-联苯-3-吡咯烷乙酰胺; 3-吡咯烷乙氰,ALPHA,ALPHA-二苯基-,(3S)
• 英文别名: (S)-2,2-Diphenyl-2-(pyrrolidin-3-yl)acetonitrile; (S)-alpha,alpha-Diphenyl-3-pyrrolidineacetamide; (S)-2,2-Diphenyl-2-(pyrrolidin-3-yl)acetamide; 2,2-Diphenyl-2-[(3S)-3-pyrrolidinyl]acetamide; 3-Pyrrolidineacetamide, α,α-diphenyl-, (3S)-; (S)-2,2-diphenyl-2-(3-pyrrolidinyl)acetonitrile; (S)-(+)-Alfa,Alfa-Diphenyl-3-Pyrrolidine acetamide; (S)-3-(1-cyano-1,1-diphenylmethyl)pyrrolidine; (S)-3-(1-Carbamoyl-1,1-diphenylmethyl)pyrrolidine; 2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetonitrile; 3-(S)-(+)-(cyano-1,1-diphenylmethyl)-pyrrolidine; 2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 488.5±45.0 °C at 760 mmHg
• 分子式: C₁₈H₂₀N₂O
• 分子量: 280.364
• 闪点: 249.2±28.7 °C
• 精确质量: 280.157562
• PSA: 55.12000
• LogP: 2.24
• 外观性状: 淡棕色粉末
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.596
• 储存条件: 2-8°C

安全

• 危害码 (欧洲): Xi
• 海关编码: 2933990090

合成路线

851645-39-1 ~99% 133099-11-3

文献：Theravance, Inc. Patent: US2005/277688 A1, 2005 ; Location in patent: Page/Page column 11 ; US 20050277688 A1

197964-14-0 ~19% 133099-11-3

文献：MEDICHEM, S.A. Patent: WO2009/153649 A1, 2009 ; Location in patent: Page/Page column 11; 12 ;

1189753-52-3 ~97% 133099-11-3

文献：Pramanik, Chinmoy; Bapat, Kiran; Chaudhari, Ashok; Tripathy, Narendra K.; Gurjar, Mukund K. Organic Process Research and Development, 2012 , vol. 16, # 10 p. 1591 - 1597

133099-09-9 ~65% 133099-11-3

文献：AUSPEX PHARMACEUTICALS, INC. Patent: US2009/5431 A1, 2009 ; Location in patent: Page/Page column 32 ; US 20090005431 A1

上下游产品

上游产品  4
851645-39-1 197964-14-0 1189753-52-3 133099-09-9
下游产品  3
133099-07-7 133099-04-4 134002-25-8

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%