364750-81-2

• 常用中文名：(2S,4S)-N-叔丁氧羰基-4-甲基吡咯烷-2-甲酸
• 常用英文名：(4S)-1-(tert-Butoxycarbonyl)-4-methyl-L-proline
• CAS号：364750-81-2
• 分子式：C₁₁H₁₉NO₄
• 分子量：229.273
• 发布时间：2019-01-02 15:30:42
• 更新时间：2026-08-02 22:38:51

名称

• 中文名: (2S,4S)-N-Boc-4-甲基吡咯烷-2-甲酸
• 英文名: (2S,4S)-N-Boc-4-Methylpyrrolidine-2-Carboxylic Acid
• 中文别名: (2S,4S)-1-(叔丁氧羰基)-4-甲基吡咯烷-2-羧酸; (4S)-1-BOC-4-甲基-L-脯氨酸; (2S,4S)-1-BOC-4-甲基-2-甲酸吡咯烷; BOC-4-ME-PRO-OH((2S,4S)-N-叔丁氧羰基-4-甲基吡咯烷-2-甲酸); (2S,4S)-N-BOC-4-甲基吡咯烷-2-甲酸/(4S)-1-BOC-4-甲基-L-脯氨酸; (2S,4S)-1-[(叔-丁氧基)羰基]-4-甲基吡咯烷-2-羧酸
• 英文别名: (4S)-1-Boc-4-Methyl-L-proline/(2S,4S)-1-(tert-butoxycbonyl)-4-Methylpyrrolidine-2-cboxylic acid; N-Boc-(4S)-4-methyl-L-proline; (2S,4S)-1-(tert-Butoxycarbonyl)-4-methylpyrrolidine-2-carboxylic acid; Rel-(2s,4s)-1-(tert-butoxycbonyl)-4-methylpyrrolidine-2-cboxylic acid; 1,2-Pyrrolidinedicboxylicacid,4-Methyl-,1-(1,1-diMethylethyl)ester,(2S,4S); 4(S)-methy-1-Boc-L-proline; N-BOC-cis-4-Methyl-L-Proline; (2S,4S)-1-(tert-Butoxycbonyl)-4-methylpyrrolidine-2-cboxylic acid; (2S,4S)-4-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid; (2s,4s)-n-boc-4-methylpyrrolidine-2-cboxylic acid; (4S)-1-Boc-4-Methyl-L-proline; (2S,4S)-4-Methyl-1,2-pyrrolidinedicboxylic acid 1-(1,1-dimethylethyl) ester; N-Boc-4-Me-Pro-OH; (4S)-4-Methyl-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline; N-tert-Butyloxycbonyl-(2S,4S)-4-methylproline; Boc-4-Me-Pro-OH

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 343.2±35.0 °C at 760 mmHg
• 分子式: C₁₁H₁₉NO₄
• 分子量: 229.273
• 闪点: 161.4±25.9 °C
• 精确质量: 229.131409
• PSA: 66.84000
• LogP: 1.05
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.491
• 储存条件: 室温，干燥

合成路线

540501-56-2 ~92% 364750-81-2

文献：Raines, Ronald T.; Shoulders, Matthew D.; Hodges, Jonathan A. Patent: US2007/275897 A1, 2007 ; Location in patent: Page/Page column 6; sheet 4 ;

1262320-71-7 ~59% 364750-81-2

文献：VERTEX PHARMACEUTICALS INCORPORATED; HENDERSON, James A.; MAXWELL, John; VAILLANCOURT, Louis; MORRIS, Mark; GREY, JR., Ronald; GIROUX, Simon; KONG, Laval Chan Chun; DAS, Sanjoy Kumar; LIU, Bingcan; POISSON, Carl; CADILHAC, Caroline; BUBENIK, Monica; REDDY, T. Jagadeeswar; FALARDEAU, Guy; YANNOPOULOS, Constantin; WANG, Jian; PEREIRA, Oswy Z.; BENNANI, Youssef L.; PIERCE, Albert C.; BHISETTI, Govinda Rao; COTTRELL, Kevin M.; MARONE, Valerie Patent: WO2011/9084 A2, 2011 ; Location in patent: Page/Page column 389 ;

84348-38-9 ~% 364750-81-2

文献：WO2012/18325 A1, ; Page/Page column 146 ; WO 2012/018325 A1

138512-73-9 ~% 364750-81-2

文献：Organic Letters, , vol. 12, # 13 p. 3018 - 3021

196394-48-6 ~% 364750-81-2

文献：WO2012/39717 A1, ;

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