522-53-2

• 常用中文名：LOBIC酸
• 常用英文名：Lobaric acid
• CAS号：522-53-2
• 分子式：C₂₅H₂₈O₈
• 分子量：456.48500
• 发布时间：2016-03-16 04:04:48
• 更新时间：2026-09-22 17:43:55
• Lobaric acid is a depsidone metabolite that has been isolated from Stereocaulon lichen species with antioxidant, antiproliferative, antiviral, and enzyme inhibitory activites. It scavenges superoxide radicals in a cell-free assay (IC50 = 97.9 μmol) and inhibits proliferation in a panel of leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic, and lung cancer cell lines (EC50s = 15.2-63.9 μg/ml). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC50 = 0.87 μM for the human recombinant enzyme) and production of 12(S)-HETE (Item No. 34570) by 12(S)-lipoxygenase (IC50 = 28.5 μM). In vivo, lobaric acid (250 μM) decreases lesion number, but not lesion diameter, in tobacco leaves infected with tobacco mosaic virus (TMV).

名称

• 中文名: LOBIC酸
• 英文名: 3-hydroxy-9-methoxy-6-oxo-7-pentanoyl-1-pentylbenzo[b][1,4]benzodioxepine-2-carboxylic acid
• 英文别名: USNETIC ACID; LOBIC ACID; Lobic acid(aS); 8-Hydroxy-3-methoxy-11-oxo-1-(1-oxopentyl)-6-pentyl-11H-dibenzo[b,e][1,4]dioxin-7-cboxylic acid; 11H-Dibenzo[b,e][1,4]dioxin-7-cboxylic acid, 8-hydroxy-3-methoxy-11-oxo-1-(1-oxopentyl)-6-pentyl; Usnetic acid; lobutoic

物化性质

• 密度: 1.265g/cm3
• 沸点: 667.9ºC at 760mmHg
• 分子式: C₂₅H₂₈O₈
• 分子量: 456.48500
• 闪点: 225.7ºC
• 精确质量: 456.17800
• PSA: 119.36000
• LogP: 5.52950
• 折射率: 1.579
• 储存条件: -20°C，密闭，干燥

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