Lobaric acid

Modify Date: 2024-01-30 12:31:23

Lobaric acid structure	Common Name	Lobaric acid
	CAS Number	522-53-2	Molecular Weight	456.48500
	Density	1.265g/cm3	Boiling Point	667.9ºC at 760mmHg
	Molecular Formula	C₂₅H₂₈O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	225.7ºC

Use of Lobaric acid

Lobaric acid is a depsidone metabolite that has been isolated from Stereocaulon lichen species with antioxidant, antiproliferative, antiviral, and enzyme inhibitory activites. It scavenges superoxide radicals in a cell-free assay (IC50 = 97.9 μmol) and inhibits proliferation in a panel of leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic, and lung cancer cell lines (EC50s = 15.2-63.9 μg/ml). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC50 = 0.87 μM for the human recombinant enzyme) and production of 12(S)-HETE (Item No. 34570) by 12(S)-lipoxygenase (IC50 = 28.5 μM). In vivo, lobaric acid (250 μM) decreases lesion number, but not lesion diameter, in tobacco leaves infected with tobacco mosaic virus (TMV).

Name	3-hydroxy-9-methoxy-6-oxo-7-pentanoyl-1-pentylbenzo[b][1,4]benzodioxepine-2-carboxylic acid
Synonym	More Synonyms

Density	1.265g/cm3
Boiling Point	667.9ºC at 760mmHg
Molecular Formula	C₂₅H₂₈O₈
Molecular Weight	456.48500
Flash Point	225.7ºC
Exact Mass	456.17800
PSA	119.36000
LogP	5.52950
Index of Refraction	1.579