109523-13-9

• 常用中文名：叔丁氧基羰基-OIC-羧酸
• 常用英文名：BOC-OIC-OH
• CAS号：109523-13-9
• 分子式：C₁₄H₂₃NO₄
• 分子量：269.33700
• 发布时间：2019-01-01 18:12:37
• 更新时间：2024-01-05 23:46:14

名称

• 中文名: 叔丁氧羰基-L-八氢化吲哚-2-羧酸
• 英文名: (2S,3aS,7aS)-1-(tert-Butoxycarbonyl)octahydro-1H-indole-2-carboxylic acid
• 中文别名: 叔丁氧基羰基-OIC-羧酸; Boc-l-八氢吲哚-2-羧酸; (2S,3aS,7aS)-八氢-1H-吲哚-1,2-二羧酸 1-叔丁酯
• 英文别名: Boc-(2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid; (2S,3aS,7aS)-Octahydro-1H-Indole-1,2-Dicarboxylic Acid 1-(1,1-Dimethylethyl) Ester; BOC-OIC-OH

物化性质

• 沸点: 400.9±28.0°C
• 熔点: 134-136°C
• 分子式: C₁₄H₂₃NO₄
• 分子量: 269.33700
• 精确质量: 269.16300
• PSA: 66.84000
• LogP: 2.57710
• 储存条件: 2-8°C

MSDS

Material Safety Data Sheet Section1. Identification of the substance Product Name: Boc-l-octahydroindole-2-carboxylic acid, 95% Synonyms: Section2. Composition/information on ingredients. Ingredient name:Boc-l-octahydroindole-2-carboxylic acid CAS number:109523-13-9 Section3. Hazards identification Harmful by inhalation, in contact with skin and if swallowed. Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately flush eyes with running water for at least 15 minutes while keeping eyes open. Seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Storage:Store in closed vessels, under −20◦C. Section8. Exposure Controls / PPE Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear chemical-resistant gloves, safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Odor:No data Boiling point:No data Melting point:No data Flash point:No data Density:No data Molecular formula: C14H23NO4 Molecular weight: 269.3 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides. Section11. Toxicological information No data Section12. Ecological information No data Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-hazardous for air and ground transportation. Section15. Regulatory information Indication of Danger: No data. Risk Statement:No data. Safety Statement:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable gloves and eye/face protection. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xi

合成路线

24424-99-5 80875-98-5 ~99% 109523-13-9

文献：WARNER-LAMBERT COMPANY LLC Patent: WO2004/92132 A1, 2004 ; Location in patent: Page 85 ;

960529-90-2 ~97% 109523-13-9

文献：Sayago, Francisco J.; Jimenez, Ana I.; Cativiela, Carlos Tetrahedron Asymmetry, 2007 , vol. 18, # 19 p. 2358 - 2364

365973-21-3 ~84% 109523-13-9

文献：Hanessian, Stephen; Ersmark, Karolina; Wang, Xiaotian; Del Valle, Juan R.; Blomberg, Niklas; Xue, Yafeng; Fjellstroem, Ola Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 12 p. 3480 - 3485

24424-99-5 ~% 109523-13-9

文献：Tetrahedron Asymmetry, , vol. 18, # 19 p. 2358 - 2364

16851-56-2 ~% 109523-13-9

文献：Tetrahedron Asymmetry, , vol. 18, # 19 p. 2358 - 2364

80828-13-3 ~% 109523-13-9

文献：Tetrahedron Asymmetry, , vol. 18, # 19 p. 2358 - 2364

192436-84-3 ~% 109523-13-9

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 12 p. 3480 - 3485

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