150-19-6

• 常用中文名：3-甲氧基苯酚
• 常用英文名：m-Methoxyphenol
• CAS号：150-19-6
• 分子式：C₇H₈O₂
• 分子量：124.137
• 相关类别： 化学试剂 有机试剂 醚类
• 发布时间：2018-06-10 08:13:12
• 更新时间：2024-01-02 12:51:00
• 3-Methoxyphenol 是一种酚类化合物,具有生物毒性。3-Methoxyphenol 可被全身吸收性,扰乱肝脏、肾脏、中枢神经系统和氧化还原过程的功能,并增加体内 Hb、红细胞和白细胞的水平。

名称

• 中文名: 3-甲氧基苯酚
• 英文名: 3-methoxyphenol
• 中文别名: 间甲氧基苯酚; 间羟基苯甲醚; 间甲氧基酚; 3-甲氧基酚; 间苯二酚单甲醚; 3-羟基苯甲醚
• 英文别名: m-Hydroxyanisole; Resorcinol methyl ether; m-Guaiacol; 3-methoxy phenol; 1-Hydroxy-3-methoxybenzene; 3-Methoxy-phenol; Resorcinol monomethyl ether; 1,3-dihydroxybenzene monomethyl ether; Phenol, 3-methoxy-; Phenol,3-methoxy; m-Hydroxyanisol; 3-Methoxyphenol; m-Methoxyphenol; 3-hydroxyanisole; EINECS 205-754-6; methyl resorcinol; MFCD00002267

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 244.3±0.0 °C at 760 mmHg
• 熔点: -17 °C
• 分子式: C₇H₈O₂
• 分子量: 124.137
• 闪点: 119.1±4.8 °C
• 精确质量: 124.052429
• PSA: 29.46000
• LogP: 1.51
• 外观性状: 透明粉红色至红色液体带有苯酚的气味
• 蒸汽压: 0.0±0.5 mmHg at 25°C
• 折射率: 1.535
• 储存条件:

  密封于干燥阴凉处保存。

• 稳定性:

  1. 常温常压下稳定。

  2. 存在于香料烟烟叶、烟气中。

  3. 天然存在于芸香油、芹菜子油、烟叶油、橙叶蒸馏液和海狸香中。

• 水溶解性: slightly soluble
• 分子结构:

  五、分子性质数据：

  1、 摩尔折射率：34.81

  2、 摩尔体积（cm³/mol）：111.8

  3、 等张比容（90.2K）：278.9

  4、 表面张力（dyne/cm）：38.6

  5、 极化率（10^-24cm³）：13.80

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:1

  3.氢键受体数量:2

  4.可旋转化学键数量:1

  5.互变异构体数量:3

  6.拓扑分子极性表面积29.5

  7.重原子数量:9

  8.表面电荷:0

  9.复杂度:83

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  一、物性数据：

  1. 性状：无色透明到淡黄色晶体，具有类似苯酚的甜香香气。暴露空气易变色。

  2. 密度（g/mL,20℃）：1.145 3. 熔点（ºC）：<-17 4. 沸点（ºC,常压）：243~246， 114ºC(666.5pa) 5. 折射率 _(n ²⁰ _D) ：1.551 6. 闪点（ºC）：>112 7. 溶解性：微溶于水，溶于乙醇等有机溶剂中。

  8. 相对密度（20℃，4℃）：1.1151⁵⁶

  9. 相对密度（25℃，4℃）：1.052¹³¹

  10. 常温折射率（n ²⁰）：1.5510

生物活性

• 描述: 3-Methoxyphenol 是一种酚类化合物,具有生物毒性。3-Methoxyphenol 可被全身吸收性,扰乱肝脏、肾脏、中枢神经系统和氧化还原过程的功能,并增加体内 Hb、红细胞和白细胞的水平。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病

MSDS

Name: 3-Methoxyphenol 97% Material Safety Data Sheet Synonym: m-Hydroxyanisol CAS: 150-19-6 Section 1 - Chemical Product MSDS Name:3-Methoxyphenol 97% Material Safety Data Sheet Synonym:m-Hydroxyanisol Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 150-19-6 3-METHOXYPHENOL 97% 205-754-6 Hazard Symbols: XN Risk Phrases: 20/21/22 36 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes. Potential Health Effects Eye: Causes severe eye irritation. Skin: May cause skin irritation. Harmful if absorbed through the skin. May cause skin discoloration. Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed. Inhalation: May cause respiratory tract irritation. Chronic: Chronic exposure may cause visual disturbances. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Skin: Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: Remove from exposure and move to fresh air immediately. Get medical aid if cough or other symptoms appear. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Water or foam may cause frothing. Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Use only in a well-ventilated area. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 150-19-6: Russia: 0.5 mg/m3 TWA Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Liquid Color: clear pink red Odor: Odor of caramel and phenol pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: 243 - 246 deg C @ 760.00mm Hg Freezing/Melting Point: -17 deg C Autoignition Temperature: Not available. Flash Point: > 112 deg C (> 233.60 deg F) Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: soluble in water Specific Gravity/Density: 1.1310g/cm3 Molecular Formula: C7H8O2 Molecular Weight: 124.14 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Bases - acid chlorides - acid anhydrides - oxidizing agents. Hazardous Decomposition Products: Carbon monoxide, carbon dioxide. Hazardous Polymerization: Will not occur. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 150-19-6: SL7524000 LD50/LC50: CAS# 150-19-6: Draize test, rabbit, eye: 5% Severe; Draize test, rabbit, eye: 100%; Draize test, rabbit, skin: 100%; Inhalation, mouse: LC50 = 11500 mg/m3/4H; Inhalation, rat: LC50 = 11500 mg/m3/4H; Oral, mouse: LD50 = 312 mg/kg; Oral, mouse: LD50 = 312 mg/kg; Oral, rat: LD50 = 597 mg/kg; Oral, rat: LD50 = 597 mg/kg; Skin, rat: LD50 = 682 mg/kg. Carcinogenicity: 3-METHOXYPHENOL - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XN Risk Phrases: R 20/21/22 Harmful by inhalation, in contact with skin and if swallowed. R 36 Irritating to eyes. Safety Phrases: S 23 Do not inhale gas/fumes/vapour/spray. S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 150-19-6: No information available. Canada CAS# 150-19-6 is listed on Canada's NDSL List. CAS# 150-19-6 is listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 150-19-6 is listed on the TSCA inventory. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 二、毒理学数据： 1、急性毒性：大鼠经口LD50：597 mg/kg； 大鼠经皮LD50：682 mg/kg； 小鼠经口LD50：312 mg/kg； 小鼠腹腔LD50：320 mg/kg。 2、 吸入毒性：大鼠LC50：11500 mg/m^3/4H； 小鼠LC50：11500 mg/m^3/4H。 3、 生殖毒性：大鼠经口TDLo：333 mg/kg 生态学数据: 三、生态学数据： 其它有害作用：该物质对环境可能有危害，对水体应给予特别注意。 CHEMICAL IDENTIFICATION RTECS NUMBER : SL7524000 CHEMICAL NAME : Phenol, m-methoxy- CAS REGISTRY NUMBER : 150-19-6 LAST UPDATED : 199701 DATA ITEMS CITED : 15 MOLECULAR FORMULA : C7-H8-O2 MOLECULAR WEIGHT : 124.15 WISWESSER LINE NOTATION : QR CO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit REFERENCE : JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 46,185,1957 ** ACUTE TOXICITY DATA ** TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Human DOSE/DURATION : 230 ug/m3/22W TOXIC EFFECTS : Behavioral - muscle weakness Behavioral - headache Behavioral - irritability REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 37(3),108,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 597 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 37(3),108,1972 TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 11500 mg/m3/4H TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,105,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 682 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 37(3),108,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 312 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 37(3),108,1972 TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 11500 mg/m3/4H TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,105,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 320 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia REFERENCE : JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 46,185,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 597 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(10),16,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 682 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(10),16,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2120 ug/m3/5H/19W-I TOXIC EFFECTS : Brain and Coverings - recordings from specific areas of CNS REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 37(3),108,1972 TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 6200 ug/m3/5H/19W-I TOXIC EFFECTS : Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 37(3),108,1972 ** REPRODUCTIVE DATA ** TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation DOSE : 230 ug/m3 SEX/DURATION : female 22 week(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - menstrual cycle changes or disorders REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 37(3),108,1972 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 333 mg/kg SEX/DURATION : female 11 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 41,43,1990

安全

• 符号: GHS05, GHS06
• 信号词: Danger
• 危害声明: H302 + H332-H311-H315-H318
• 警示性声明: P280-P305 + P351 + P338-P312
• 个人防护装备: Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
• 危害码 (欧洲): Xn:Harmful;
• 风险声明 (欧洲): R20/21/22;R36/37/38
• 安全声明 (欧洲): S26-S36/37/39
• 危险品运输编码: UN 2810 6.1/PG 3
• WGK德国: 3
• RTECS号: SL7524000
• 包装等级: III
• 危险类别: 6.1
• 海关编码: 29095090

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制备

1. 烟草：OR，26。

海关

海关编码	2909500000
中文概述	2909500000. 醚酚、醚醇酚及其卤化、磺化、硝化或亚硝化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%