70774-25-3

• 常用中文名：流柔比星
• 常用英文名：Leurubicin
• CAS号：70774-25-3
• 分子式：C₃₃H₄₀N₂O₁₂
• 分子量：656.67700
• 发布时间：2018-08-21 21:39:39
• 更新时间：2026-08-23 16:35:04

名称

• 中文名: 流柔比星
• 英文名: Leurubicin
• 英文别名: leucine-doxorubicin; (8S,10S)-10-[[3-(Leucylamino)-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione; N-(L-Leucyl)doxorubicin; 5,12-Naphthacenedione, 10-[[3-[[(2S)-2-amino-4-methyl-1-oxopentyl]amino]-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, (8S,10S); 5,12-Naphthacenedione, -(2S)-2-amino-4-methyl-1-oxopentylamino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyloxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S,10S); L-Leucyldoxorubicin; N-leucyldoxorubicin; Leurubicina; (8S,10S)-10-[(3-L-Leucylamino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione

物化性质

• 密度: 1.49g/cm3
• 沸点: 916.2ºC at 760 mmHg
• 分子式: C₃₃H₄₀N₂O₁₂
• 分子量: 656.67700
• 闪点: 507.9ºC
• 精确质量: 656.25800
• PSA: 235.17000
• LogP: 1.62340
• 折射率: 1.666

合成路线

25316-40-9 ~% 70774-25-3

文献：Chung, Da-Eun; Kratz, Felix Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 19 p. 5157 - 5163

35661-60-0 ~% 70774-25-3

文献：Garsky; Lumma; Feng; Wai; Ramjit; Sardana; Oliff; Jones; DeFeo-Jones; Freidinger Journal of Medicinal Chemistry, 2001 , vol. 44, # 24 p. 4216 - 4224

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