19121-58-5

• 常用中文名：澳洲茄碱
• 常用英文名：Solasonine
• CAS号：19121-58-5
• 分子式：C₄₅H₇₃NO₁₆
• 分子量：884.058
• 相关类别： 天然产物 生物碱
• 发布时间：2018-07-05 15:52:31
• 更新时间：2026-08-02 17:51:52
• Solasonine 是从龙葵中分离出一种甾体糖苷生物碱,对人胃癌细胞有细胞毒性。

名称

• 中文名: 澳洲茄碱
• 英文名: Solasonine
• 中文别名: SOLASONINE 澳洲茄碱; 澳洲茄碱;澳州茄碱; (2S,3R,4S,5S,6R)-2-(((2R,3S,4S,5R,6R)-3-羟基-2-(羟甲基)-6-(((4S,5'R,6,6BS,8AS,8BR,9S,10R,11AS,12AS,12BS)-5',6A,8A,9-四甲基-1,3,4,5,6,6A,6B,7,8,8A,8B,9,11A,12,12A,12B-十六碳氢螺[萘并[2',1':4,5]茚并[2,1-B]呋喃-10,2'-哌啶]-4-基)氧基)-5-(((2S,3R,4R,5R,6S)-3,4,5-三羟基-6-甲基四氢-2H; 索拉索宁; Α-澳洲茄碱,茄解碱; 澳洲茄碱(Α-澳洲茄碱; Solasonine #天然产物 HY-N0070; 澳洲茄鹼; 澳洲茄碱(标准品); Α-澳洲茄碱; 羥基茄鹼; 茄解碱; 澳州茄碱; 澳洲茄碱(对照品); 澳洲茄碱-龙葵; α-澳洲茄碱; 奥洲茄碱; 澳洲茄碱(Α-澳洲茄碱, 茄解碱); 澳洲茄碱-龙葵(最多卖); (2S,3R,4S,5S,6R)-2-(((2R,3S,4S,5R,6R)-3-羟基-2-(羟甲基)-6-(((4S,5'R,6,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9-四甲基-1,3,4,5,6,6a,6b,7,8,8a,8b,9,11a,12,12a,12b-十六碳氢螺[萘并[2',1':4,5]茚并[2,1-b]呋喃-10,2'-哌啶]-4-基)氧基)-5-(((2S,3R,4R,5R,6S)-3,4,5-三羟基-6-甲基四氢-2H-吡喃-2-基)氧基)四氢-2H-吡喃-4-基)氧基)-6-(羟甲基)四氢-2H-吡喃-3,4,5-三醇
• 英文别名: Solasonine extrapure; PURAPURIN; SOLASONINE; Purapurine; SOLANINE S; Solasonine (6CI, 7CI, 8CI); Solasonine 19-5; ALPHA-SOLASONINE; Solanine-S; SOLASONIN; (3β,22α,25R)-Spirosol-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-glucopyranosyl-(1->;3)]-β-D-galactopyranoside; α-Solasonine-RM; SOLASODAMINE; β-D-Galactopyranoside, (3β,22α,25R)-spirosol-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]; (2S,3R,4S,5S,6R)-2-(((2R,3S,4S,5R,6R)-3-hydroxy-2-(hydroxymethyl)-6-(((2'S,4S,5'R,6,6bS,8aS,8bR,9S,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,4,5,6,6a,6b,7,8,8a,8b,9,11a,12,12a,12b-hexadecahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-piperidin]-4-yl)oxy)-5-(((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-4-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; (3b,22a,25R)-Spirosol-5-en-3-yl O-6-Deoxy-a-L-mannopyranosyl(1®2)-O-[b-D-glucopyranosyl(1®3)]-b-D-galactopyranoside; SOLASONINE(RG); UNII:TR60638HXL; SOLANCARPIN; 5-SOLASODEN-3BETA-OL 3-O-6-D-DEOXY-ALPHA-L-MONOPYRANOSYL (1-)-BETA-D-GLUCOPYRANOSYL (1-)-BETA-D-GALACTOPYRANOSIDE; α-Solasonine; Solasoonine; [(22R,25R)-Spirosol-5-en-3β-yl]2-O-(6-deoxy-α-L-mannopyranosyl)-3-O-(β-D-glucopyranosyl)-β-D-galactopyranoside; (2S,3R,4S,5S,6R)-2-(((2R,3S,4S,5R,6R)-3-Hydroxy-2-(hydroxymethyl)-6-(((4S,5'R,6,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,4,5,6,6a,6b,7,8,8a,8b,9,11a,12,12a,12b-hexadecahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-piperidin]-4-yl)oxy)-5-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-4-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; SOLANCPIN; Solasonine alpha-Solasonine; beta.-D-Galactopyranoside, (3.beta.,22.alpha.,25R)-spirosol-5-en-3-yl O-6-deoxy-.alpha.-L-mannopyranosyl-(12)-O-.beta.-D-glucopyranosyl-(13); PURAPURINE

物化性质

• 密度: 1.4±0.1 g/cm3
• 熔点: 301-303℃
• 分子式: C₄₅H₇₃NO₁₆
• 分子量: 884.058
• 精确质量: 883.492920
• PSA: 258.71000
• LogP: 4.35
• 折射率: 1.628
• 储存条件: 2-8C

生物活性

• 描述: Solasonine 是从龙葵中分离出一种甾体糖苷生物碱,对人胃癌细胞有细胞毒性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Ding X, et al. Purification, antitumor activity in vitro of steroidal glycoalkaloids from black nightshade (Solanum nigrum L.). Food Chem. 2013 Nov 15;141(2):1181-6.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : WF1450000 CHEMICAL NAME : Solasonine CAS REGISTRY NUMBER : 19121-58-5 LAST UPDATED : 198207 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C45-H73-N-O16 MOLECULAR WEIGHT : 884.19 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 77300 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 15,285,1977

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