787-93-9

• 常用中文名：4-氨基-N-(2,6-二甲基苯基)苯甲酰胺
• 常用英文名：Ameltolide
• CAS号：787-93-9
• 分子式：C₁₅H₁₆N₂O
• 分子量：240.30000
• 发布时间：2018-08-09 07:15:35
• 更新时间：2024-01-02 12:22:58
• Ameltolide, a 4-aminobenzamide derivative, is an anticonvulsant agent which has been shown to be effective at inhibiting seizures in animal models.

名称

• 中文名: 氨托利
• 英文名: 4-amino-N-(2,6-dimethylphenyl)benzamide
• 中文别名: 4-氨基-N-(2,6-二甲基苯基)苯甲酰胺
• 英文别名: 4-Amino-2',6'-benzoxylidide; Ameltolide

物化性质

• 密度: 1.182g/cm3
• 沸点: 340.8ºC at 760 mmHg
• 分子式: C₁₅H₁₆N₂O
• 分子量: 240.30000
• 闪点: 159.9ºC
• 精确质量: 240.12600
• PSA: 55.12000
• LogP: 3.79210
• 折射率: 1.656

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DM5325000 CHEMICAL NAME : 2',6'-Benzoxylidide, 4-amino- CAS REGISTRY NUMBER : 787-93-9 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C15-H16-N2-O MOLECULAR WEIGHT : 240.33 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 161 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EPILAK Epilepsia (New York). (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) Ser.1-3: 1909-55; Ser.4: V.1- 1959- Volume(issue)/page/year: 29,198,1988 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 4095 mg/kg/13W-I TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Liver - changes in liver weight Related to Chronic Data - death REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 19,197,1992 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 600 mg/kg SEX/DURATION : female 6-17 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 44,37,1991 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1300 mg/kg SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 44,37,1991

安全

• 海关编码: 2924299090

合成路线

64594-44-1 ~91% 787-93-9

文献：Vamecq, Joseph; Lambert, Didier; Poupaert, Jacques H.; Masereel, Bernard; Stables, James P. Journal of Medicinal Chemistry, 1998 , vol. 41, # 18 p. 3307 - 3313

87-62-7 16106-38-0 ~% 787-93-9

文献：Bembenek, Scott D.; Hocutt, Frances M.; Leonard, JR., Barry Eastman; Rabinowitz, Michael H.; Rosen, Mark D.; Tarantino, Kyle T.; Venkatesan, Hariharan Patent: US2010/204226 A1, 2010 ; Location in patent: Page/Page column 60 ;

122-04-3 87-62-7 ~% 787-93-9

文献：Research Corporation Patent: US4638014 A1, 1987 ;

122-04-3 ~% 787-93-9

文献：Vamecq, Joseph; Lambert, Didier; Poupaert, Jacques H.; Masereel, Bernard; Stables, James P. Journal of Medicinal Chemistry, 1998 , vol. 41, # 18 p. 3307 - 3313

87-62-7 ~% 787-93-9

文献：Vamecq, Joseph; Lambert, Didier; Poupaert, Jacques H.; Masereel, Bernard; Stables, James P. Journal of Medicinal Chemistry, 1998 , vol. 41, # 18 p. 3307 - 3313

上下游产品

上游产品  4
64594-44-1 87-62-7 16106-38-0 122-04-3
下游产品  1
51616-07-0

海关

海关编码	2924299090
中文概述	2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%