Ameltolide

Modify Date: 2025-08-27 19:44:09

Ameltolide Structure
Ameltolide structure
Common Name Ameltolide
CAS Number 787-93-9 Molecular Weight 240.30000
Density 1.182g/cm3 Boiling Point 340.8ºC at 760 mmHg
Molecular Formula C15H16N2O Melting Point N/A
MSDS N/A Flash Point 159.9ºC

 Use of Ameltolide


Ameltolide, a 4-aminobenzamide derivative, is an anticonvulsant agent which has been shown to be effective at inhibiting seizures in animal models.

 Names

Name 4-amino-N-(2,6-dimethylphenyl)benzamide
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.182g/cm3
Boiling Point 340.8ºC at 760 mmHg
Molecular Formula C15H16N2O
Molecular Weight 240.30000
Flash Point 159.9ºC
Exact Mass 240.12600
PSA 55.12000
LogP 3.79210
Index of Refraction 1.656
InChIKey HZIWGOAXOBPQGY-UHFFFAOYSA-N
SMILES Cc1cccc(C)c1NC(=O)c1ccc(N)cc1

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DM5325000
CHEMICAL NAME :
2',6'-Benzoxylidide, 4-amino-
CAS REGISTRY NUMBER :
787-93-9
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C15-H16-N2-O
MOLECULAR WEIGHT :
240.33

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
161 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPILAK Epilepsia (New York). (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) Ser.1-3: 1909-55; Ser.4: V.1- 1959- Volume(issue)/page/year: 29,198,1988 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
4095 mg/kg/13W-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Liver - changes in liver weight Related to Chronic Data - death
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 19,197,1992 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
600 mg/kg
SEX/DURATION :
female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 44,37,1991
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1300 mg/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 44,37,1991

 Safety Information

HS Code 2924299090

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 AmeltolideBioassay

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Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344
Name: Toxicity was determined in rats at a dose of 30 mg/kg after 4 hour. (- denotes no act...
Source: ChEMBL
Target: N/A
External Id: CHEMBL816504
Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898
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 Synonyms

4-Amino-2',6'-benzoxylidide
Ameltolide
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