Ameltolide

Modify Date: 2024-01-02 12:22:58

Ameltolide structure	Common Name	Ameltolide
	CAS Number	787-93-9	Molecular Weight	240.30000
	Density	1.182g/cm3	Boiling Point	340.8ºC at 760 mmHg
	Molecular Formula	C₁₅H₁₆N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	159.9ºC

Use of Ameltolide

Ameltolide, a 4-aminobenzamide derivative, is an anticonvulsant agent which has been shown to be effective at inhibiting seizures in animal models.

Name	4-amino-N-(2,6-dimethylphenyl)benzamide
Synonym	More Synonyms

Density	1.182g/cm3
Boiling Point	340.8ºC at 760 mmHg
Molecular Formula	C₁₅H₁₆N₂O
Molecular Weight	240.30000
Flash Point	159.9ºC
Exact Mass	240.12600
PSA	55.12000
LogP	3.79210
Index of Refraction	1.656

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DM5325000

CHEMICAL NAME :: 2',6'-Benzoxylidide, 4-amino-

CAS REGISTRY NUMBER :: 787-93-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C15-H16-N2-O

MOLECULAR WEIGHT :: 240.33

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 161 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPILAK Epilepsia (New York). (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) Ser.1-3: 1909-55; Ser.4: V.1- 1959- Volume(issue)/page/year: 29,198,1988 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 4095 mg/kg/13W-I

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Liver - changes in liver weight Related to Chronic Data - death

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 19,197,1992 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 600 mg/kg

SEX/DURATION :: female 6-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 44,37,1991

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1300 mg/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 44,37,1991

HS Code	2924299090

N-(2,6-dimethyl...

CAS#:64594-44-1

~91%

Ameltolide

CAS#:787-93-9

Literature: Vamecq, Joseph; Lambert, Didier; Poupaert, Jacques H.; Masereel, Bernard; Stables, James P. Journal of Medicinal Chemistry, 1998 , vol. 41, # 18 p. 3307 - 3313

2,6-xylidine

CAS#:87-62-7

4-aminobenzoyl ...

CAS#:16106-38-0

Ameltolide

CAS#:787-93-9

Literature: Bembenek, Scott D.; Hocutt, Frances M.; Leonard, JR., Barry Eastman; Rabinowitz, Michael H.; Rosen, Mark D.; Tarantino, Kyle T.; Venkatesan, Hariharan Patent: US2010/204226 A1, 2010 ; Location in patent: Page/Page column 60 ;

4-Nitrobenzoyl ...

CAS#:122-04-3

2,6-xylidine

CAS#:87-62-7

Ameltolide

CAS#:787-93-9

Literature: Research Corporation Patent: US4638014 A1, 1987 ;

4-Nitrobenzoyl ...

CAS#:122-04-3

Ameltolide

CAS#:787-93-9

Literature: Vamecq, Joseph; Lambert, Didier; Poupaert, Jacques H.; Masereel, Bernard; Stables, James P. Journal of Medicinal Chemistry, 1998 , vol. 41, # 18 p. 3307 - 3313

2,6-xylidine

CAS#:87-62-7

Ameltolide

CAS#:787-93-9

Literature: Vamecq, Joseph; Lambert, Didier; Poupaert, Jacques H.; Masereel, Bernard; Stables, James P. Journal of Medicinal Chemistry, 1998 , vol. 41, # 18 p. 3307 - 3313

Precursor 4
CAS#:64594-44-1 N-(2,6-dimethyl... CAS#:87-62-7 2,6-xylidine CAS#:16106-38-0 4-aminobenzoyl ... CAS#:122-04-3 4-Nitrobenzoyl ...
DownStream 1
CAS#:51616-07-0 N-(2,6-dimethyl...

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

4-Amino-2',6'-benzoxylidide

Ameltolide

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Ameltolide
Price: Click To Check
Purity: 95.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Ameltolide
Price: $550.0/100mg $850.0/250mg $1800.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-(4-AMINO-2-METHYLPHENYL)BUTANAMIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Ameltolide

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