569-65-3

• 常用中文名：美克洛嗪
• 常用英文名：Meclozine
• CAS号：569-65-3
• 分子式：C₂₅H₂₈Cl₂N₂
• 分子量：427.40900
• 相关类别： 原料药 抗变态反应药 抗组胺药
• 发布时间：2018-07-18 14:25:11
• 更新时间：2026-07-01 07:01:08
• 【用途一】
  用作表面活性剂，印染行业作渗透剂

名称

• 中文名: 美克洛嗪
• 英文名: 1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine
• 中文别名: 1-[(4-氯苯基)苯甲基]-4-[(3-甲苯基)甲基]-哌嗪; 甲醇中美克洛嗪标准溶液; 芬钠西泮; 美克力嗪杂质; 甲氯嗪; 敏克静; 1-((4-氯苯基)(苯基)甲基)-4-(3-甲基苄基)哌嗪; 美其敏; 氯苯苄嗪
• 英文别名: Suprimal; Vomisseis; Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]- (9CI); Travelon; Monamine; Itinerol; 1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)piperazine; Bonadettes; Navicalm; Siguran; Sabi; 1-(p-Chloro-a-phenylbenzyl)-4-(m-methylbenzyl)piperazine; 1-(P-CHLORO-ALPHA-PHENYLBENZYL)-4-(M-METHYLBENZYL)-PIPERAZIN; Histamethine; Bonadoxin; Histamethizine; neo-Suprimel; U. C. B; neo-Suprimal; 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)-piperazin 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)piperazine 1-(p-chlorobenzhydryl)-4-(m-methylbenzyl)diethylenediamine 1-(p-chlorobenzhydryl)-4-(m-methylbenzyl)piperazine 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine 1-p-chlorobenzhydryl-4-m-methylbenzylpiperazine ancolan antivert; MECLOZINE; 1-[(RS)-(4-Chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine; mecilizine; 1-[(4-chlorophenyl)-phenyl-methyl]-4-[(3-methylphenyl)methyl]piperazine; Postafene; 1-[(4-Chlorophenyl)(phenyl)methyl]-4-(3-methylbenzyl)piperazine; Ravelon; Meclozine //BP; Pachloramine; Mex; Histametizine; 1-(p-Chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)piperazine; Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]; 1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)diethylenediamine; Chiclida; Ancolan; Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl); EINECS 209-323-3; Sea-Legs; MFCD00242697; meclizine; Ancolon; Calmonal; Vomissels; MECLIZINE; Piperazine, 1-(p-chloro-a-phenylbenzyl)-4-(m-methylbenzyl)- (6CI, 8CI); 1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)diethylenediami; Subi; Bonine; Peremesin; Histametizyne; 1-[(4-Chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine; Neo-Istafene; Parachloramine; 2-Methyl Meclizine IsoMer; 1-(4-chloro-benzhydryl)-4-(3-methyl-benzyl)-piperazine

物化性质

• 密度: 1.159 g/cm3
• 沸点: 1.5 g/100 mL (25ºC)
• 熔点: 153-157ºC
• 分子式: C₂₅H₂₈Cl₂N₂
• 分子量: 427.40900
• 闪点: 253.3ºC
• 精确质量: 426.16300
• PSA: 6.48000
• LogP: 6.23340
• 储存条件: 室温，密闭，干燥

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TL1970000 CHEMICAL NAME : Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)- CAS REGISTRY NUMBER : 569-65-3 BEILSTEIN REFERENCE NO. : 0332002 LAST UPDATED : 199706 DATA ITEMS CITED : 16 MOLECULAR FORMULA : C25-H27-Cl-N2 MOLECULAR WEIGHT : 390.99 WISWESSER LINE NOTATION : T6N DNTJ AYR&R DG& D1R C1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1750 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 9,134,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1650 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 625 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported DOSE : 1500 ug/kg SEX/DURATION : female 48-69 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,222,1963 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 600 mg/kg SEX/DURATION : female 13-16 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - homeostasis REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 17,67,1970 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 400 mg/kg SEX/DURATION : female 7-10 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 2,303,1963 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1400 mg/kg SEX/DURATION : female 8-15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 9,134,1968 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1 gm/kg SEX/DURATION : female 8-15 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - other developmental abnormalities REFERENCE : PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 9,134,1968 *** REVIEWS *** TOXICOLOGY REVIEW BCSTB5 Biochemical Society Transactions. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1973- Volume(issue)/page/year: 2,695,1974 TOXICOLOGY REVIEW ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966 TOXICOLOGY REVIEW AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960- Volume(issue)/page/year: 112,99,1966 TOXICOLOGY REVIEW ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 28,135,1971 TOXICOLOGY REVIEW BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 1,1476,1963 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83063 No. of Facilities: 805 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 805 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83063 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 18 (estimated) No. of Female Employees: 18 (estimated)

安全

• 危害码 (欧洲): Xn
• 风险声明 (欧洲): R22;R36/37/38
• 安全声明 (欧洲): S26-S37/39
• 海关编码: 2933599090

合成路线

5321-48-2 104-88-1 ~% 569-65-3

文献：J. Pharm. Belg. , , vol. 10, p. 239,244

上下游产品

上游产品  2
5321-48-2 104-88-1
下游产品  0

制备

【方法一】
将1-对氯二苯甲基-4-苄基哌嗪溶于乙醇，在镍催化剂存在下，于10MPa氢压下在150℃反应6h。滤出催化剂，真空蒸馏，分离出对氯二苯甲基哌嗪。然后加入研细的氨基钠，加热回流1h，反应物冷却后加入间甲基苄基氯，产物进行后处理，得氯苯甲嗪。

海关

海关编码	2933599090
中文概述	2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%