6029-87-4

• 常用中文名：暗黄猪屎豆碱
• 常用英文名：Fulvine
• CAS号：6029-87-4
• 分子式：C₁₆H₂₃NO₅
• 分子量：309.35800
• 相关类别： 研究领域 心血管疾病
• 发布时间：2018-09-26 08:42:59
• 更新时间：2024-01-09 17:34:54
• Fulvine 是从 Crotalaria fulva 的种子中分离得到的吡啶生物碱。Fulvine 具有肝脏毒性 (hepatotoxic),可用于动物模型中的高血压性肺血管疾病的诱发。

名称

• 中文名: 暗黄猪屎豆碱
• 英文名: 2H-[1,6]Dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione,4,5,8,10,12,13,13a,13b-octahydro-4-hydroxy-3,4,5-trimethyl-,(3R,4S,5S,13aR,13bR)- (9CI)
• 英文别名: fulvine; 13-Epicrispatine; Fulvine (8ci)

物化性质

• 密度: 1.27g/cm3
• 沸点: 552.8ºC at 760 mmHg
• 分子式: C₁₆H₂₃NO₅
• 分子量: 309.35800
• 闪点: 288.1ºC
• 精确质量: 309.15800
• PSA: 76.07000
• LogP: 0.43040
• 折射率: 1.563
• 储存条件: -20°C

生物活性

• 描述: Fulvine 是从 Crotalaria fulva 的种子中分离得到的吡啶生物碱。Fulvine 具有肝脏毒性 (hepatotoxic),可用于动物模型中的高血压性肺血管疾病的诱发。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. J M Kay, et al.Fulvine and the pulmonary circulation. Thorax

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : RC1300000 CHEMICAL NAME : 20-Norcrotalanan-11,15-dione, 14,19-dihydro-13-hydroxy-, (12-xi,13-xi)- CAS REGISTRY NUMBER : 6029-87-4 LAST UPDATED : 199712 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C16-H23-N-O5 MOLECULAR WEIGHT : 309.40 WISWESSER LINE NOTATION : T55-11- 1A P EN IOV NVO BUTJ K1 LQ L1 M1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 40 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 40 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 40 mg/kg SEX/DURATION : female 9-12 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 20 mg/kg SEX/DURATION : female 9-12 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 20 mg/kg SEX/DURATION : female 9-12 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - body wall Reproductive - Specific Developmental Abnormalities - musculoskeletal system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 20 mg/kg SEX/DURATION : female 9-12 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - urogenital system TYPE OF TEST : Sex chromosome loss and nondisjunction MUTATION DATA TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 10 mmol/L REFERENCE : JOGNAU Journal of Genetics. (Belghoria, India) V.1-63, 1910-77. Discontinued. Volume(issue)/page/year: 59,273,1966

安全

• 危害码 (欧洲): T+