30273-41-7

30273-41-7结构式

常用中文名：2,4-二溴-6-甲基苯胺
常用英文名：4,6-Dibromo-o-toluidine
CAS号：30273-41-7
分子式：C₇H₇Br₂N
分子量：264.945
发布时间：2018-08-08 17:17:57
更新时间：2024-01-12 11:18:17
作医药中间体，用于生产新型祛痰剂溴己胺盐酸盐（必嗽平）。

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中文名	2,4-二溴-6-甲基苯胺
英文名	2,4-Dibromo-6-methylaniline
中文别名	6-甲基-2,4-二溴苯胺 4,6-二溴邻甲基苯胺
英文别名	3.5-Dibrom-2-amino-toluol MFCD00735681 2,4-Dibromo-6-methylaniline Benzenamine, 2,4-dibromo-6-methyl- 4,6-Dibromo-o-toluidine 2,3-O-ISOPROPYLIDENE-D-ALLONIC ACID 4.6-Dibrom-o-toluidin 2,4-dibromo-6-methyl-aniline

密度	1.9±0.1 g/cm3
沸点	281.2±35.0 °C at 760 mmHg
熔点	44-49ºC
分子式	C₇H₇Br₂N
分子量	264.945
闪点	123.9±25.9 °C
精确质量	262.894501
PSA	26.02000
LogP	3.72
外观性状	灰白色至灰色或淡棕色结晶粉末
蒸汽压	0.0±0.6 mmHg at 25°C
折射率	1.642
储存条件	密闭于阴凉干燥环境中
稳定性	遵照规定使用和储存则不会分解。
分子结构	1、摩尔折射率：50.69 2、摩尔体积（cm³/mol）：140.3 3、等张比容（90.2K）：371.7 4、表面张力（dyne/cm）：49.2 5、极化率（10^-24cm³）：20.09
计算化学	1.疏水参数计算参考值（XlogP）:3 2.氢键供体数量:1 3.氢键受体数量:1 4.可旋转化学键数量:0 5.互变异构体数量:无 6.拓扑分子极性表面积26 7.重原子数量:10 8.表面电荷:0 9.复杂度:118 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1. 性状：针状结晶体 2. 密度（g/mL,25/4℃）：无可用 3. 相对蒸汽密度（g/mL,空气=1）：无可用 4. 熔点（ºC）：44-49 5. 沸点（ºC,常压）：无可用 6. 沸点（ºC,5.2kPa）：无可用 7. 折射率：无可用 8. 闪点（ºC）：无可用 9. 比旋光度（º）：无可用 10. 自燃点或引燃温度（ºC）：无可用 11. 蒸气压（kPa,25ºC）：无可用 12. 饱和蒸气压（kPa,60ºC）：无可用 13. 燃烧热（KJ/mol）：无可用 14. 临界温度（ºC）：无可用 15. 临界压力（KPa）：无可用 16. 油水（辛醇/水）分配系数的对数值：无可用 17. 爆炸上限（%,V/V）：无可用 18. 爆炸下限（%,V/V）：无可用 19. 溶解性：溶于乙醇。可随蒸汽挥发

Name:	2 4-Dibromo-6-methylaniline Material Safety Data Sheet
Synonym:	2-Amino-3,5-dibromotoluene4,6-Dibromo-o-toluidin
CAS:	30273-41-7

Section 1 - Chemical Product MSDS Name:2 4-Dibromo-6-methylaniline Material Safety Data Sheet
Synonym:2-Amino-3,5-dibromotoluene4,6-Dibromo-o-toluidin

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
30273-41-7	2,4-Dibromo-6-methylaniline		unlisted

Hazard Symbols: XN
Risk Phrases: 20/21/22 36/37/38

Section 3 - HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW
Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. Harmful if absorbed through the skin.
Ingestion:
Harmful if swallowed. May cause irritation of the digestive tract.
Inhalation:
Harmful if inhaled. Causes respiratory tract irritation.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 30273-41-7: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: off-white to brown
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 44-49 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C7H7Br2N
Molecular Weight: 264.95

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen bromide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 30273-41-7 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2,4-Dibromo-6-methylaniline - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
WGK (Water Danger/Protection)
CAS# 30273-41-7: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 30273-41-7 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 30273-41-7 is not listed on the TSCA inventory.
It is for research and development use only.

SECTION 16 - ADDITIONAL INFORMATION
N/A

生态学数据:

该物质对环境可能有危害，对水体应给予特别注意。

危害码 (欧洲)	Xn: Harmful;
风险声明 (欧洲)	R20/21/22;R36/37/38
安全声明 (欧洲)	36/37/39-26
海关编码	2921430090

海关编码	2921430090
中文概述	2921430090 甲苯胺及其衍生物以及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 原产地证据文件及编号(例附原产地证书, 原产于欧盟的
Summary	HS:2921430090 toluidines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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