9050-04-8

• 常用中文名：羧甲基纤维素钙
• 常用英文名：carboxymethylcellulose calcium (1.5 g) (as)
• CAS号：9050-04-8
• 分子式：C₂₃H₃₀ClN₃O
• 分子量：399.957
• 相关类别： 食品添加剂 增稠剂
• 发布时间：2018-06-15 11:54:56
• 更新时间：2024-01-05 12:14:39
• 羧甲基纤维素钙可用作赋形剂。药用辅料,或称药用辅料,是指除药物成分外,在制药过程中使用的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,可以提高药物制剂的稳定性、溶解性和加工性。药用赋形剂还影响共同给药药物的吸收、分布、代谢和消除(ADME)过程[1]。

名称

• 中文名: 羧甲基纤维素钙
• 英文名: N4-(2-Chloro-7-methoxy-9-acridinyl)-N1,N1-diethyl-1,4-pentanediamine
• 英文别名: N-(2-Chloro-7-methoxy-9-acridinyl)-N,N-diethyl-1,4-pentanediamine; Carboxymethyloxysuccinate; 2-Oxa-1,3,4-butantricarbonsaeure; 2-(carboxymethyloxy)butanedioic acid; carboxymethyl ether,calcium salt; CARBOXYMETHYLOXYSUCCINIC ACID; (Carboxymethoxy) succinic acid; 1,4-Pentanediamine, N-(2-chloro-7-methoxy-9-acridinyl)-N,N-diethyl-; carboxymethyl cellulose-calcium

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 557.1±50.0 °C at 760 mmHg
• 分子式: C₂₃H₃₀ClN₃O
• 分子量: 399.957
• 闪点: 290.7±30.1 °C
• 精确质量: 399.207733
• PSA: 40.62000
• LogP: 5.22
• 外观性状: 白色至淡黄色固体
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.623
• 储存条件: 室温，密封

生物活性

• 描述: 羧甲基纤维素钙可用作赋形剂。药用辅料,或称药用辅料,是指除药物成分外,在制药过程中使用的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,可以提高药物制剂的稳定性、溶解性和加工性。药用赋形剂还影响共同给药药物的吸收、分布、代谢和消除(ADME)过程[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : FJ5850000 CHEMICAL NAME : Cellulose, carboxymethyl ether, calcium salt CAS REGISTRY NUMBER : 9050-04-8 LAST UPDATED : 199701 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4400 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity Kidney, Ureter, Bladder - changes in bladder weight REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(2),29,1993 TYPE OF TEST : LC - Lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >300 mg/m3 TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(2),29,1993 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6800 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity Kidney, Ureter, Bladder - changes in bladder weight REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(2),29,1993 TYPE OF TEST : LC - Lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >300 mg/m3 TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(2),29,1993 TYPE OF TEST : LC - Lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : >300 mg/m3 TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(2),29,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 52 mg/m3/17W-I TOXIC EFFECTS : Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(2),29,1993 TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 52 mg/m3/17W-I TOXIC EFFECTS : Blood - changes in erythrocyte (RBC) count REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(2),29,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2450 No. of Facilities: 23 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 738 (estimated) No. of Female Employees: 369 (estimated)

安全

• 符号: GHS08
• 信号词: Danger
• 危害声明: H317-H334
• 警示性声明: P261-P280-P284-P304 + P340-P342 + P311
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 3912310000

制备

羧甲基纤维素钠的水溶液内添加氢氧化钙，使其沉淀而得。

海关

海关编码	3912310000