262368-30-9

• 常用中文名：N-(4-氨基苯基)-N,4-二甲基-1-哌嗪乙酰胺
• 常用英文名：N-(4-Aminophenyl)-N,4-dimethyl-1-piperazineacetamide
• CAS号：262368-30-9
• 分子式：C₁₄H₂₂N₄O
• 分子量：262.351
• 发布时间：2018-12-25 16:22:17
• 更新时间：2026-07-16 10:14:02

名称

• 中文名: N-(4-氨基苯基)-N-甲基-2-(4-甲基哌嗪-1-基)乙酰胺
• 英文名: N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
• 中文别名: 尼达尼布杂质; N-(4-氨基苯基)-N,4-二甲基-1乙酰胺; N-(4-氨基苯基)-N,4-二甲基-1-哌嗪乙酰胺/BIBF; 尼达尼布中间体; 尼达尼布杂质44对照品; N-(4-氨基苯基)-N-甲基-2-(4-甲基哌嗪-1-YL)乙酰胺; 宁达尼布杂质2; 4-二甲基-1-哌嗪乙酰胺; N-(4-氨基苯基)-N,4-二甲基; N-(4-氨基苯基)-N,4-二甲基-1-哌嗪乙酰胺(尼达尼布中间体); N-(4-氨基苯基)-N,4-二甲基-1-哌嗪乙酰胺 BIBF1120中间体; N-(4-氨基苯基)-N; N-(4-氨基苯基)-N,N'-二甲基-1-哌嗪乙酰胺; 乙磺酸尼达尼布KSM2; N-(4-氨基苯基)-N,4-二甲基-1-哌嗪乙酰胺(尼达尼布中间体,BIBF-1120中间体); 乙磺酸尼达尼布中间体262-9; N-(4-氨基苯基)-N-甲基-2-(4-甲基-1-哌嗪基)乙酰胺
• 英文别名: Nintedanib Impurity; N-[(4-methyl-piperazin-1-yl)-methylcarbonyl]-N-methyl-p-phenyldiamine; N-(4-aminophenyl)-N-4-dimethyl-1-perazineacetamide; 1-Piperazineacetamide, N-(4-aminophenyl)-N,4-dimethyl; N-(4-Aminophenyl)-N,4-Dimethyl-1-Piperazineacetamide(Under Development); N-(4-Aminophenyl)-N-methyl-2-(4-methyl-1-piperazinyl)acetamide; N-[(4-methyl-piperazin-1-yl)-methylcarbonyl]-N-methyl-p-phenylendiamine; N-(4-Aminophenyl)-n-methyl-2-(4-methylpiperazin-1-yl)acetamide; N-[(4-methyl-piperazin-1-yl)methylcbonyl]-N-methyl-p-phenylendiamine; N-(4-Aminophenyl)-N,4-dimethylpiperazine-1-acetamide; N- (4-aminophenyl) -N-methyl-2 - (4-methylpiperazine-1-yl) acetamide; Nidanib Impurities 61; N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetami; N-methyl-2-(4-methylpiperazin-1-yl); Nintedanib Intermediate 2; N-[(4-methyl-piperazin-1-yl)-methylcarbonyl]-N-methyl-p-phenylenediamine; N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl) acetamide(Nintedanib acetamide compound)

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 434.8±40.0 °C at 760 mmHg
• 分子式: C₁₄H₂₂N₄O
• 分子量: 262.351
• 闪点: 216.7±27.3 °C
• 精确质量: 262.179352
• PSA: 52.81000
• LogP: -0.86
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.598
• 储存条件: 室温，干燥

安全

• 海关编码: 2933599090

合成路线

109-01-3 2653-16-9 ~70% 262368-30-9

文献：WO2012/68441 A2, ; Page/Page column 13; 14 ;

1139453-98-7 ~80% 262368-30-9

文献：Journal of Medicinal Chemistry, , vol. 52, # 14 p. 4466 - 4480

100-15-2 ~% 262368-30-9

文献：WO2012/68441 A2, ;

上下游产品

上游产品  4
109-01-3 2653-16-9 1139453-98-7 100-15-2
下游产品  1
656247-17-5

海关

海关编码	2933599090
中文概述	2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%