22235-81-0

• 常用中文名：N-Isopropylnoratropine
• 常用英文名：N-Isopropylnoratropine (NINA)
• CAS号：22235-81-0
• 分子式：C₁₉H₂₇NO₃
• 分子量：317.42300
• 发布时间：2016-12-01 21:14:04
• 更新时间：2026-07-16 08:00:16
• N-Isopropylnoratropine is used in the synthesis of ipratropium, a bronchodilator compound with nonselective muscarinic antagonist activity.

名称

• 中文名: N-异丙基神经氨酸
• 英文名: N-Isopropyl Noratropine
• 中文别名: (1R,3R,5S)-3-[(2RS)-3-羟基-2-苯基丙酰氧基]-8-异丙基-8-氮杂双环[3.2.1]辛烷; 异丙托溴铵杂质13; N-异丙基去甲阿托品(异丙托溴铵杂质E); N-异丙基去甲阿托品; 异丙托溴铵 杂质 E(N-异丙基去甲托品); 异丙托溴铵一水合物杂质E; 异丙托溴铵杂质13(异丙托溴铵杂质E); N-异丙基诺阿托品; N-异丙基去甲托品,10 MM DMSO 溶液; 异丙托溴铵去甲基杂质; 异丙托溴铵杂质E对照品; 异丙托品杂质E; (1R,3R,5S)-8-异丙基-8-氮杂双环[3.2.1]辛-3-基3-羟基-2-苯基丙酸酯 (异丙托溴铵杂质); 异丙托溴铵杂质E(N-异丙基去甲阿托品)
• 英文别名: Benzeneacetic acid, α-(hydroxymethyl)-, (3-endo)-8-(1-methylethyl)-8-azabicyclo[3.2.1]oct-3-yl ester; (1R,3r,5S)-8-Isopropyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate (Ipratropium Impurity); (1R,3r,5S)-8-isopropyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate; endo-(1)-8-Aza-8-isopropylbicyclo(3.2.1)oct-3-yl (hydroxymethyl)phenylacetate; Ipratropium Bromide Impurity E; Ipratropium Impurity E; NIsopropylnoratropine,N Isopropylnoratropine; N-Isopropyl Noratropine (Ipratropium Bromide Impurity E); N-Isopropylnoratropine; YB-M2; Ipratropium Bromide Impurity 13(Ipratropium Impurity E); Ipratropium Bromide Impurity 13（Ipratropium Bromide Impurity E）; endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate; (8-propan-2-yl-8-azabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate; rac-(R*)-α-(Hydroxymethyl)benzeneacetic acid (1R,5S)-8-isopropyl-8-azabicyclo[3.2.1]octane-3α-yl ester; Ipratropium Bromide Impurity E (N-Isopropyl Noratropine); N-Isopropylnoratropine, 10 mM in DMSO; N-DesMethyl IpratropiuM; α-(HydroxyMethyl)benzeneacetic Acid (3-Endo)-8-(1-Methylethyl)-8-azabicyclo[3.2.1]- oct-3-yl Ester; α-(HydroxyMethyl)benzeneacetic Acid endo-8-(1-Methylethyl)-8- azabicyclo[3.2.1]oct-3-yl Ester; Ipratropium Bromide Impurity 13

物化性质

• 密度: 1.15g/cm3
• 沸点: 448.8ºC at 760 mmHg
• 分子式: C₁₉H₂₇NO₃
• 分子量: 317.42300
• 闪点: 225.2ºC
• 精确质量: 317.19900
• PSA: 49.77000
• LogP: 2.64740
• 蒸汽压: 7.72E-09mmHg at 25°C
• 折射率: 1.567
• 储存条件: -20°C，密闭，干燥

安全

• 海关编码: 2933990090

合成路线

67-64-1 16839-98-8 ~63% 22235-81-0

文献：Issa, Fatiah; Kassiou, Michael; Chan, Hak-Kim; McLeod, Malcolm D. Australian Journal of Chemistry, 2006 , vol. 59, # 1 p. 53 - 58

51-55-8 ~% 22235-81-0

文献：Issa, Fatiah; Kassiou, Michael; Chan, Hak-Kim; McLeod, Malcolm D. Australian Journal of Chemistry, 2006 , vol. 59, # 1 p. 53 - 58

14510-37-3 ~% 22235-81-0

文献：Tsyskovskaia, Irina; Kandil, Mustapha; Beaumier, Yves Synthetic Communications, 2007 , vol. 37, # 3 p. 439 - 446

3423-25-4 ~% 22235-81-0

文献：Tsyskovskaia, Irina; Kandil, Mustapha; Beaumier, Yves Synthetic Communications, 2007 , vol. 37, # 3 p. 439 - 446

上下游产品

上游产品  5
67-64-1 16839-98-8 51-55-8 14510-37-3
3423-25-4
下游产品  0

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%