1189516-65-1

• 常用中文名：帕潘立酮棕榈酸酯氧化杂质
• 常用英文名：9-Keto Risperidone
• CAS号：1189516-65-1
• 分子式：C₂₃H₂₅FN₄O₃
• 分子量：424.468
• 发布时间：2018-09-25 13:18:11
• 更新时间：2026-07-11 19:57:47

名称

• 中文名: 帕潘立酮棕榈酸酯氧化杂质
• 英文名: 9-Keto Risperidone
• 中文别名: 哌啶酮杂质1 (互变异构体混合物); 帕利培酮杂质1; 9-酮帕利哌酮杂质; 3-(2-(4-(6-氟苯并[D]异噁唑-3-基)哌啶-1-基)乙基)-2-甲基-7,8-二氢-4H-吡啶并[1,2-A]嘧啶-4,9(6H)-二酮; 哌啶酮杂质1; 帕利哌酮05; 帕潘立酮9-酮杂质; 3-[2-[4-(6-氟-1,2-苯并异恶唑-3-基)-1-哌啶基]乙基]-6,7,8,9-四氢-2-甲基-4H-吡啶并[1,2-Α]嘧啶-4; 帕利哌酮9-酮杂质; 利培酮9-酮杂质; 9-酮利培酮杂质; 9-酮基利培酮; 3-(2-(4-(6-氟代苯并[D]异恶唑-3-基)哌啶-1-基)乙基)-2-甲基-7,8-二氢-4H-吡啶并[1,2-A]嘧啶-4,9(6H)-二酮; 帕利哌酮9-酮杂质(互变异构体的混合物); 帕利哌酮杂质对照品H; PALIPERIDONE 9-酮杂质; 帕潘立酮杂质2(9-酮帕潘立酮)
• 英文别名: 9-Keto Risperidone/Keto paliper; Paliperidone 9-Keto Impurity (9-Keto Risperidone/ 9-Oxo Risperidone); Paliperidone 9-one impurity; 9-ketoliperone; 9-oxo-risperidone; 3-(2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-7,8-dihydro-4H-pyrido[1,2-a]pyrimidine-4,9(6H)-dione; Paliperidone Impurity: 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-7,8-dihydro-2-methyl-4H-pyrido[1,2-a]pyrimidine-4,9(6H)-dione (9-Keto Risperidone ); Paliperidone 9-Keto Impurity; Paliperidone impurity 11/Paliperidone 9-Keto Impurity/3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-7,8-dihydro-2-methyl-4H-pyrido[1,2-a]pyrimidine-4,9(6H)-dione; paliperidon Impurity 3; 3-{2-[4-(6-Fluoro-1,2-benzoxazol-3-yl)-1-piperidinyl]ethyl}-2-methyl-7,8-dihydro-4H-pyrido[1,2-a]pyrimidine-4,9(6H)-dione; 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-7,8-dihydro-2-Methyl-4H-pyrido[1,2-a]pyriMidine-4,9(6H)-dione; Paliperidone 9-Keto Impurity/ Impurity E; 4H-Pyrido[1,2-a]pyrimidine-4,9(6H)-dione, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-7,8-dihydro-2-methyl; 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-7,8-dihydro-6H-pyrido[1,2-a]pyrimidine-4,9-dione; Risperidone 9-Oxo Impurity; Paliperidone Impurity 2(9-Keto Paliperidone); Paliperidone Impurity 1 （Mixture of Tautomeric Isomers）; Paliperidone Ketone; Paliperidone 9-Keto Impurity (Mixture of Tautomeric Isomers); 9-Keto Risperidone/ 9-Oxo Risperidone (Paliperidone 9-Keto Impurity)

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 594.7±60.0 °C at 760 mmHg
• 分子式: C₂₃H₂₅FN₄O₃
• 分子量: 424.468
• 闪点: 313.5±32.9 °C
• 精确质量: 424.191071
• PSA: 81.23000
• LogP: 1.60
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.692

合成路线

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