130049-82-0

• 常用中文名：3-(2-氯乙基)-6,7,8,9-四氢-9-羟基-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮
• 常用英文名：3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
• CAS号：130049-82-0
• 分子式：C₁₁H₁₅ClN₂O₂
• 分子量：242.702
• 相关类别： 医药中间体 杂环化合物 吡啶类化合物 乙基吡啶
• 发布时间：2018-06-11 08:15:29
• 更新时间：2026-07-03 07:12:34
• 【医药中间体】
  3-(2-氯乙基)-6,7,8,9-四氢-9-羟基-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮（130049-82-0）是帕潘利酮侧链，用于治疗精神分裂症和双相狂躁症药物帕潘立酮的中间体。

名称

• 中文名: 3-(2-氯乙基)-6,7,8,9-四氢-9-羟基-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮
• 英文名: 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
• 中文别名: 3-(2-氯乙基)-6,7,8,9-四氢-9-羟基-2-甲基-4H-吡啶; 帕利哌酮杂质55; 3-(2-氯乙基)-6,7,8,9-四氢-9-羟基-2-甲基-4H-吡啶并[1,2-A]嘧; 帕潘立酮/ 3-(2-氯乙基)-6,7,8,9-四氢-9-羟基-2-甲基-4H-吡啶并[1,2-A]嘧啶-4-酮; 帕潘立酮中间体1; 帕立哌酮相关化合物 C; 3-(2-氯乙基)-6,7,8,9-四氢-9-羟基-2-甲基-4H-吡啶并[1,2-1]嘧啶-4-酮,帕潘立酮中间体; 2-甲基-3-(2-氯)乙基-9-羟基-6,7,8,9-四氢-4H-吡啶并[1,2-A]嘧啶-4-酮; 3-(2-氯乙基) -9-羟基- 2-甲基-6,7,8,9-四氢吡啶并[1,2-Α]嘧啶-4-酮 (棕榈酸帕利哌酮起始原料; 帕潘立酮RC C; 帕利哌酮相关物质C; 帕利哌酮杂质N; 3-(2-氯乙基)-9-羟基-2-甲基-6,7,8,9-四氢吡啶[1,2-A]嘧啶-4-酮; 帕潘立酮杂质N; 帕潘立酮相关化合物C; 2氯乙基吡啶并嘧啶; 帕潘立酮杂质9(帕潘立酮RC C); 帕利哌酮杂质; 帕利哌酮杂质08; 帕利哌酮杂质9; 帕利哌酮相关化合物C; 帕潘立酮中间体/3-(2-氯乙基)-6,7,8,9-四氢-9-羟基-2-甲基-4H-吡啶并[1,2-A]嘧啶-4-酮; 3-(2-氯乙基)-6,7,8,9-四 氢-9-羟基-2-甲基-4H-叱 啶并[1,2-A]嘧啶-4-酮; 帕潘立通中间体; 3-(2-氯乙基)-6,7,8,9-四氢-9-羟基-2-甲基-4H-吡啶并[1,2-A]嘧啶-4-酮,帕潘立酮中间体; 帕潘立酮相关物质C; 3-(2-氯乙基)-2-甲基-9-羟基-6,7,8,9-四氢-4H-哌啶[1,2-A]嘧啶-4-酮; 帕潘立酮杂质9(帕潘立酮相关杂质C)
• 英文别名: 3-(2-Chloroethyl)-9-hydroxy-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one; 4H-pyrido[1,2-a]pyrimidine-4-one; )-6,7,8,9-tetrahydro-9-hydroxy-2-methyL; Paliperidone Intermediate 1; 9-Hydroxy-3-(2-chloroethyl)-2-Methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyriMidin-4-one; Paliperidone Related Compound C (20 mg) (3-(2-Chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-alpha]pyrimidin-4-one); 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-p; 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one ISO 9001：2015 REACH; Paliperidone Impurity 9（Paliperidone Related Compound C）; Paliperidone Related Compound C (3-(2-Chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[; 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidine-4-one; 3-(2-chloroethyl)-9-hydroxy-2-Methyl-4H,6H,7H,8H,9H-pyrido[1,2-a]pyriMidin-4-one; Paliperidone Impurity 9(Paliperidone RC C); 3-(2-Chloroethy)-6,7,8,9- Tetrahydro-2-methyl-4H- pyrido-(1,2-a) pyrimidine-4- one, Hydrochloride; Paliperidone Related Compound C; 3-(2-Chloroethyl)-2-methyl-9-hydroxy-6,7,8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-one; 3-(2-ChL; 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 130-0; Paliperidone Related Compound C (3-(2-Chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-alpha]pyrimidin-4-one); Paliperidone Related CoMpound C; 3-(2-Chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one; Paliperidone Impurities105; 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-α]pyrimidin-4-one; Paliperidone Chloro IMpurity RelatedCoMpound C); Paliperidone Int 1; Paliperidone-8; 3-(2-CHLORETHYL)-9-HYDROXY-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1，2-A]PYRIMIDIN-4-ONE; 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-on; Paliperidone Impurity: (3-(2-Chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-alpha]pyrimidin-4-one); 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrimidin-4-one; "3-(2-Chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido-[1,2-a] pyrimidine-4-one"; 3-(2-CHLOROETHYL)-9-HYDROXY-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE; 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one; Paliperidone Related Compound C (Paliperidone Chloroethyl Impurity); Paliperidone RC C; 3-(2-Chloro)-2-methyl-9-hydroxy-6,7,8,9-tetrahydro-4H-piperido[1,2-a]pyrimidin-4-one; 3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one; 4H-Pyrido[1,2-a]pyriMidin-4-one,3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-Methyl; 3-(2-chloroethyl)-9-hydroxy-2-methyl; 9-tetrahydro-9-hydroxy-2-Methyl; (2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one; 3-(2-CHLOROEETHYL)-6,7,8,9-TETRAHYDRO-9-HYDROXY-2-METHYL-4H-PYRIDO (1,2-A) PYRIMIDIN-4-ONE; 3-(2-Chloroethyl)-6,7; Paliperidone Impurity 55; 3-(2-Chlorethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-on; Paliperidone IMpurity N

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 389.3±52.0 °C at 760 mmHg
• 熔点: 100-102°C
• 分子式: C₁₁H₁₅ClN₂O₂
• 分子量: 242.702
• 闪点: 189.2±30.7 °C
• 精确质量: 242.082199
• PSA: 55.12000
• LogP: 0.26
• 外观性状: 一种近乎于灰白色或灰色粉末
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.635
• 储存条件: Refrigerator

安全

• 危害码 (欧洲): Xi
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2933990090

上下游产品

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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%