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1380424-42-9

1380424-42-9结构式

中文名	KML29
英文名	1,1,1,3,3,3-Hexafluoro-2-propanyl 4-[bis(1,3-benzodioxol-5-yl)(hy droxy)methyl]-1-piperidinecarboxylate
中文别名	KML 29,MAGL抑制剂 1,1,1,3,3,3-六氟丙-2-基 4-(双(苯并[D][1,3]二氧杂环戊烷-5-基)(羟基)甲基)哌啶-1-甲酸酯抑制剂KML29
英文别名	1,1,1,3,3,3-hexafluoropropan-2-yl acrylate Acrylic Acid 1,1,1,3,3,3-Hexafluoroisopropyl Ester 1-Piperidinecarboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester 4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester 1-Piperidinecboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-cboxylate 1,1,1,3,3,3-hexafluoroprop-2-yl acrylate KML-29 KML29, 10 mM in DMSO KML29 hexafluoro-2-propyl acrylate KML29 (KML-29) Hexafluoroisopropyl acrylate 1,1,1,3,3,3-hexafluoropropan-2-yl 4-[bis(2H-1,3-benzodioxol-5-yl)(hydroxy)methyl]piperidine-1-cboxylate 1,1,1,3,3,3-Hexafluoro-2-propanyl 4-[bis(1,3-benzodioxol-5-yl)(hydroxy)methyl]-1-piperidinecarboxylate LPS,allodynia,Monoacylglycerol lipase,KML29,MAGL,inhibit,2-AG,Inhibitor,HFIP,KML 29,KML-29 1,1,1,3,3,3-hexafluoroisopropylacrylate KML29;KML-29;KML 29

描述	KML29是一种有效的选择性MAGL抑制剂, 抑制人, 小鼠, 和大鼠脑蛋白酶时, IC50 分别为5.9, 15, 和 43 nM。
相关类别	信号通路 >> 代谢酶/蛋白酶 >> MAGL 研究领域 >> 代谢疾病
参考文献	[1]. Chang JW, et al. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem Biol. 2012 May 25;19(5):579-588. [2]. Ignatowska-Jankowska BM,et al. In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects. Br J Pharmacol. 2014 Mar;171(6):1392-1407.