103733-49-9

• 常用中文名：喹那普利相关物质A
• 常用英文名：Quinapril Diketopiperazine
• CAS号：103733-49-9
• 分子式：C₂₅H₂₈N₂O₄
• 分子量：420.50
• 发布时间：2016-11-09 10:49:00
• 更新时间：2026-08-31 17:02:29
• PD 109488是喹那普利二酮哌嗪的代谢产物[1]。

名称

• 中文名: 喹那普利相关物质A
• 英文名: Quinapril Diketopiperazine
• 中文别名: 盐酸喹那普利杂质Ⅰ [3S-[2(R* ),3Α,11ΑΒ]]-1,3,4,6,11,11Α-六氢-3-甲基-1,4-二氧代-Α-(2-苯乙基)-2H-吡嗪并[1,2-B]异喹啉-2-乙酸乙酯; 喹那普利RC A; 喹那普利杂质4 (喹那普利杂质D); 盐酸喹那普利杂质Ⅰ [3S-[2（R* ），3α，11αβ]]-1，3，4，6，11，11α-六氢-3-甲基-1，4-二氧代-α-（2-苯乙基）-2H-吡嗪并[1，2-b]异喹啉-2-乙酸乙酯; 喹那普利杂质5; 盐酸喹那普利杂质D; 喹那普利杂质Ⅰ; 喹那普利相关化合物A; 奎那普利杂质D; 喹那普利相关物质A 标准品; 乙基(2S)-2-[(3S,11AS)-3-METHYL-1,4-DIOXO-1,3,4,6,11,11A-HEXAHYDRO-2H-PYRAZINO[1,2-B]ISOQUINOLIN-2-YL]-4-PHENYLBUTANOATE 标准品; 喹那普利杂质I[3S-[2(R*),3A,11AΒ]]-1,3,4,6,11,11A-六氢-3-甲基-1,4-二氧代-Α-(2-苯乙基)-2H-吡嗪并[1,2-B]异喹啉-2-乙酸乙酯; 喹那普利杂质D杂质A); 喹那普利杂质D; 喹那普利二酮哌嗪
• 英文别名: Quinapril Related Compound A (50 mg) (Ethyl [3S-[(2R*), 3a, 11ab]]-1,3,4,6,11,11a-hexahydro-3-methyl-1,4-dioxo-a-(2-phenylethyl)-2H-pyrazino[1,2-b]isoquinoline-2-acetate); Quinapril Impurity Ⅰ; ethyl (2S)-2-[(3S,11aS)-3-methyl-1,4-dioxo-3,6,11,11a-tetrahydropyrazino[1,2-b]isoquinolin-2-yl]-4-phenylbutanoate; Quinapril hydrochloride Related Compound A: ethyl (2S)-2-[(3S,11aS)-3-methyl-1,4-dioxo-1,3,4,6,11,11a-hexahydro-2H-pyrazino[1,2-b]isoquinolin-2-yl]-4-phenylbutanoate (Quinapril hydrochloride Imp. D ); Quinapril RC A; (alphaS,3S,11aS)-1,3,4,6,11,11a-Hexahydro-3-methyl-1,4-dioxo-alpha-(2-phenylethyl)-2H-pyrazino[1,2-b]isoquinoline-2-acetic acid ethyl ester; (aS,3S,11aS)-1,3,4,6,11,11a-Hexahydro-3-methyl-1,4-dioxo-α-(2-phenylethyl)-2H-pyrazino[1,2-β]isoquinoline-2-acetic Acid; 2H-Pyrazino[1,2-b]isoquinoline-2-acetic acid, 1,3,4,6,11,11a-hexahydro-3-methyl-1,4-dioxo-α-(2-phenylethyl)-, ethyl ester, (αS,3S,11aS); (S)-ethyl 2-((3S,11aS)-3-methyl-1,4-dioxo-3,4,11,11a-tetrahydro-1H-pyrazino[1,2-b]isoquinolin-2(6H)-yl)-4-phenylbutanoate; QUINAPRIL RELATED COMPOUND A (50 MG) (ETHYL[3S-[2(R*),3A,11A BETA]]-1,3,4,6,11,11A-HEXAHYDRO-3-METHYL-1,4-DIOXO-ALPHA-(2-PHENY-LETHYL)-2H-PYRAZINO[1,2-B]ISOQUINOLINE-2-ACETATE); Quinapril Impurity D (Quinapril Related Compound A); Quinapril Impurity 4（Quinapril Impurity D）; Quinapril Related Compound A (Ethyl[3S-[2(R*),3a,11a beta]]-1,3,4,6,11,11a-hexahydro-3-methyl-1,4-d; Quinapril Hydrochloride Impurity D; 2H-Pyrazino(1,2-B)isoquinoline-2-acetic acid, 1,3,4,6,11,11A-hexahydro-3-methyl-1,4-dioxo-alpha-(2-phenylethyl)-, ethyl ester, (3S-(2(R*),3alpha-11abeta)); Ethyl (2S)-2-[(3S,11aS)-3-Methyl-1; Quinapril Impurity D; (aS,3S,11aS)-1,3,4,6,11,11a-Hexahydro-3-methyl-1,4-dioxo-a-(2-phenylethyl)-2H-pyrazino[1,2-b]isoquinoline-2-acetic Acid; Quinapril Impurity D/ Quinapril Related Compound A (Quinapril Diketopiperazine); Ethyl [3S-[2(R*),3a,11a beta]]-1,3,4,6,11,11a-hexahydro-3-methyl-1,4-dioxo-alpha-(2-phenylethyl)-2H-pyrazino[1,2-b]isoquinoline-2-acetate; (αS,3S,11aS)-1,3,4,6,11,11a-Hexahydro-3-methyl-1,4-dioxo-α-(2-phenylethyl)-2H-pyrazino[1,2-b]isoquinoline-2-acetic Acid; Quinapril impurity A; Quinapril Related Compound A(Secondy Standds traceble to; Quinapril Hydrochloride Impurity Ⅰ：Quinapril Diketopiperazine; ethyl (2S)-2-[(3S,11aS)-3-methyl-1,4-dioxo-1,3,4,6,11,11a-hexahydro-2H-pyrazino[1,2-b]isoquinolin-2-yl]-4-phenylbutanoate; Ethyl (2S)-2-[(3S,11aS)-3-Methyl-1,4-dioxo-1,3,4,6,11,11a-hexahydro-2H-pyrazino[1,2-b]isoquinolin-2; (αS,3S,11aS)-1,3,4,6,11,11a-Hexahydro-3-methyl-1,4-dioxo-α-(2-phenylethyl)-2H-pyrazino[1,2-b]isoquinoline-2-acetic acid ethyl ester; Quinapril Impurity Ⅰ Ethyl[3S-[2(R*),3a,11a β]]-1,3,4,6,11,11a-hexahydro- 3-methyl-1,4-dioxo-α -(2-phenylethyl)-2H-pyrazino[1 ,2-b]isoquinoline-2-acetate; Quinapril Related Compound A

物化性质

• 密度: 1.25g/cm3
• 沸点: 644.5ºC at 760 mmHg
• 分子式: C₂₅H₂₈N₂O₄
• 分子量: 420.50
• 闪点: 343.6ºC
• 精确质量: 420.20500
• PSA: 66.92000
• LogP: 2.61090
• 蒸汽压: 1.68E-16mmHg at 25°C
• 折射率: 1.617

生物活性

• 描述: PD 109488是喹那普利二酮哌嗪的代谢产物[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. A R Kugler, et al. Determination of quinapril and quinaprilat by high-performance liquid chromatography with radiochemical detection, coupled to liquid scintillation counting spectrometry. J Chromatogr B Biomed Appl. 1995 Apr 21;666(2):360-7.

安全

• 危险品运输编码: NONH for all modes of transport

合成路线

85441-61-8 ~77% 103733-49-9

文献：Klutchko; Blankley; Fleming; Hinkley; Werner; Nordin; Holmes; Hoefle; Cohen; Essenburg Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1953 - 1961

74163-81-8 ~% 103733-49-9

文献：Klutchko; Blankley; Fleming; Hinkley; Werner; Nordin; Holmes; Hoefle; Cohen; Essenburg Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1953 - 1961

77497-74-6 ~% 103733-49-9

文献：Klutchko; Blankley; Fleming; Hinkley; Werner; Nordin; Holmes; Hoefle; Cohen; Essenburg Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1953 - 1961

80828-26-8 ~% 103733-49-9

文献：Klutchko; Blankley; Fleming; Hinkley; Werner; Nordin; Holmes; Hoefle; Cohen; Essenburg Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1953 - 1961

82586-56-9 ~% 103733-49-9

文献：Klutchko; Blankley; Fleming; Hinkley; Werner; Nordin; Holmes; Hoefle; Cohen; Essenburg Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1953 - 1961

82586-55-8 ~% 85441-61-8 103733-49-9

文献：Li; Guo; Zografi Pharmaceutical Research, 2002 , vol. 19, # 1 p. 20 - 26

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