917251-94-6

• 常用中文名：8-chloro-5-fluoro-2-(trifluoromethyl)-1H-quinolin-4-one
• 常用英文名：8-chloro-5-fluoro-2-(trifluoromethyl)-1H-quinolin-4-one
• CAS号：917251-94-6
• 分子式：C₁₀H₄ClF₄NO
• 分子量：265.59100
• 发布时间：2017-02-10 20:27:58
• 更新时间：2025-09-19 11:13:47

名称

• 英文名: 8-chloro-5-fluoro-2-(trifluoromethyl)-1H-quinolin-4-one
• 英文别名: 8-chloro-5-fluoro-2-(trifluoromethyl)quinolin-4-ol

物化性质

• 分子式: C₁₀H₄ClF₄NO
• 分子量: 265.59100
• 精确质量: 264.99200
• PSA: 33.12000
• LogP: 3.75170

合成路线

452-83-5 372-31-6 ~52% 917251-94-6

文献：Wyeth Patent: US2007/27160 A1, 2007 ; Location in patent: Page/Page column 60-61 ; US 20070027160 A1

400-36-2 452-83-5 ~49% 917251-94-6

文献：Childers, Wayne E.; Havran, Lisa M.; Asselin, Magda; Bicksler, James J.; Chong, Dan C.; Grosu, George T.; Shen, Zhongqi; Abou-Gharbia, Magid A.; Bach, Alvin C.; Harrison, Boyd L.; Kagan, Natasha; Kleintop, Teresa; Magolda, Ronald; Marathias, Vasilios; Robichaud, Albert J.; Sabb, Annmarie L.; Zhang, Mei-Yi; Andree, Terrance H.; Aschmies, Susan H.; Beyer, Chad; Comery, Thomas A.; Day, Mark; Grauer, Steven M.; Hughes, Zoe A.; Rosenzweig-Lipson, Sharon; Platt, Brian; Pulicicchio, Claudine; Smith, Deborah E.; Sukoff-Rizzo, Stacy J.; Sullivan, Kelly M.; Adedoyin, Adedayo; Huselton, Christine; Hirst, Warren D. Journal of Medicinal Chemistry, 2010 , vol. 53, # 10 p. 4066 - 4084