917251-94-6

917251-94-6 structure

917251-94-6 structure

Name: 8-chloro-5-fluoro-2-(trifluoromethyl)-1H-quinolin-4-one
Chemical Name: 8-chloro-5-fluoro-2-(trifluoromethyl)-1H-quinolin-4-one
CAS Number: 917251-94-6
Molecular Formula: C₁₀H₄ClF₄NO
Molecular Weight: 265.59100
Create Date: 2017-02-10 20:27:58
Modify Date: 2024-01-13 21:48:37

Name	8-chloro-5-fluoro-2-(trifluoromethyl)-1H-quinolin-4-one
Synonyms	8-chloro-5-fluoro-2-(trifluoromethyl)quinolin-4-ol

Molecular Formula	C₁₀H₄ClF₄NO
Molecular Weight	265.59100
Exact Mass	264.99200
PSA	33.12000
LogP	3.75170

452-83-5 structure

452-83-5

372-31-6 structure

372-31-6

~52%

917251-94-6 structure

917251-94-6

Literature: Wyeth Patent: US2007/27160 A1, 2007 ; Location in patent: Page/Page column 60-61 ; US 20070027160 A1

400-36-2 structure

400-36-2

452-83-5 structure

452-83-5

~49%

917251-94-6 structure

917251-94-6

Literature: Childers, Wayne E.; Havran, Lisa M.; Asselin, Magda; Bicksler, James J.; Chong, Dan C.; Grosu, George T.; Shen, Zhongqi; Abou-Gharbia, Magid A.; Bach, Alvin C.; Harrison, Boyd L.; Kagan, Natasha; Kleintop, Teresa; Magolda, Ronald; Marathias, Vasilios; Robichaud, Albert J.; Sabb, Annmarie L.; Zhang, Mei-Yi; Andree, Terrance H.; Aschmies, Susan H.; Beyer, Chad; Comery, Thomas A.; Day, Mark; Grauer, Steven M.; Hughes, Zoe A.; Rosenzweig-Lipson, Sharon; Platt, Brian; Pulicicchio, Claudine; Smith, Deborah E.; Sukoff-Rizzo, Stacy J.; Sullivan, Kelly M.; Adedoyin, Adedayo; Huselton, Christine; Hirst, Warren D. Journal of Medicinal Chemistry, 2010 , vol. 53, # 10 p. 4066 - 4084