917392-54-2

• 常用中文名：4-甲基-3-[[4-(3-吡啶基)-2-嘧啶基]氨基]苯甲酸甲酯
• 常用英文名：methyl 4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoate
• CAS号：917392-54-2
• 分子式：C₁₈H₁₆N₄O₂
• 分子量：320.345
• 发布时间：2019-01-09 09:41:17
• 更新时间：2026-07-15 13:02:53

名称

• 中文名: 4-甲基-3-[[4-(3-吡啶基)-2-嘧啶基]氨基]苯甲酸甲酯
• 英文名: Methyl 4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoate
• 中文别名: 盐酸尼洛替尼INT2-IMP1; 尼罗甲酯; 4-甲基-3-{[4-(3-呲啶基)-2-嘧啶基]氨基}苯甲酸甲酯; 尼罗替尼杂质12 (尼罗替尼杂质G); 盐酸尼罗替尼杂质G; 4-甲基-3-(4-(吡啶-3-基)嘧啶-2-基氨基)苯甲酸甲酯; 4-甲基-3-[[4-(3-吡啶基)-2-嘧啶基]氨基]苯甲酸甲脂; 盐酸尼洛替尼杂质G; 尼洛替尼杂质E; 尼洛替尼杂质G; 尼罗替尼杂质G; 4-甲基-3-((4-(吡啶-3-基)嘧啶-2-基)氨基)苯甲酸甲酯
• 英文别名: Methyl 4-Methyl-3-((4-(pyridin-3-yl)pyriMidin-2-yl)amino)benzoate, Methyl 4-Methyl-3-(4-(pyridin-3-yl)pyriMidin-2-ylaMino)benzoate; Methyl 4-methyl-3-{[4-(3-pyridinyl)-2-pyrimidinyl]amino}benzoate; Methyl 4-Methyl-3-((4-(pyridin-3-yl)pyriMidin-2-yl)amino)benzoate; Nilotinib Impurity 44; Nilotinib Hydrochloride Monohydrate Impurity G; NILOTINIB IMPURITY G; Benzoic acid, 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-, methyl ester; 4-Methyl-3-(4-pyridin-3-yl-pyriMidin-2-ylaMino)-benzoic acid Methyl ester; Benzoicacid, 4-Methyl-3-[[4-(3-pyridinyl)-2-pyriMidinyl]amino]-, Methyl ester; methyl 4-methyl-3-[[4-(3-pyridyl)pyrimidin-2-yl]amino]benzoate; methyl 4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzoate; 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino; methyl 4-methyl-3-[[4-(3-pyridyl)pyrimidin-2-yl]amino]benzoa; Nilotinib Impurity 12 (Nilotinib Impurity G); Vitamin B6 Impurity; 917-2; 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid methyl ester

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 538.6±60.0 °C at 760 mmHg
• 熔点: 148-150 °C
• 分子式: C₁₈H₁₆N₄O₂
• 分子量: 320.345
• 闪点: 279.5±32.9 °C
• 精确质量: 320.127319
• PSA: 77.00000
• LogP: 3.15
• 外观性状: 固体
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.634
• 储存条件: 室温， 避光

安全

• 危害码 (欧洲): Xn

合成路线

1025716-99-7 55314-16-4 ~% 917392-54-2

文献：WO2008/137605 A1, ; Page/Page column 25; 26 ; WO 2008/137605 A1

90347-66-3 66521-66-2 ~82% 917392-54-2

文献：Kalesh, Karunakaran A.; Liu, Kai; Yao, Shao Q. Organic and Biomolecular Chemistry, 2009 , vol. 7, # 24 p. 5129 - 5136

104901-43-1 66521-66-2 ~95% 917392-54-2

文献：Ueda, Satoshi; Su, Mingjuan; Buchwald, Stephen L. Journal of the American Chemical Society, 2012 , vol. 134, # 1 p. 700 - 706

1025716-98-6 55314-16-4 ~% 641569-94-0 917392-54-2

文献：US2008/300268 A1, ; Page/Page column 59-60 ;

350-03-8 ~% 917392-54-2

文献：Journal of the American Chemical Society, , vol. 134, # 1 p. 700 - 706

55314-16-4 ~% 917392-54-2

文献：Journal of the American Chemical Society, , vol. 134, # 1 p. 700 - 706