13189-98-5

• 常用中文名：福多司坦
• 常用英文名：Fudosteine
• CAS号：13189-98-5
• 分子式：C₆H₁₃NO₃S
• 分子量：179.237
• 相关类别： 生物化工 常见氨基酸及蛋白质类药
• 发布时间：2018-05-11 08:00:00
• 更新时间：2024-01-05 11:25:03
• Fudosteine是黏液活性剂和MUC5AC粘蛋白过度分泌抑制剂。
• 1.气道黏液过度分泌作用的抑制机制，抑制杯状细胞过度形成。
  2.黏液修复作用。
  3.浆液性气道分泌亢进作用。
  4.抗炎症作用。

名称

• 中文名: 福多斯坦
• 英文名: Fudosteine
• 中文别名: 福多司坦; 弗多司坦; (-)-(R)-2-氨基-3-(3-羟丙基硫代)丙酸
• 英文别名: FUDESTEINE; fudosteine; S-(3-Hydroxypropyl)-L-cysteine; L-Cysteine, S-(3-hydroxypropyl)-; MFCD00899873

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 354.5±42.0 °C at 760 mmHg
• 熔点: 210.9-212.5ºC
• 分子式: C₆H₁₃NO₃S
• 分子量: 179.237
• 闪点: 168.2±27.9 °C
• 精确质量: 179.061615
• PSA: 108.85000
• LogP: -0.10
• 外观性状: 灰白色结晶
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.558
• 储存条件: -20°C Freezer

生物活性

• 描述: Fudosteine是黏液活性剂和MUC5AC粘蛋白过度分泌抑制剂。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Ueno-Iio, T., et al., Effect of fudosteine, a cysteine derivative, on airway hyperresponsiveness, inflammation, and remodeling in a murine model of asthma. Life Sci, 2013. 92(20-21): p. 1015-23.

  [2]. Rhee, C.K., et al., Effect of fudosteine on mucin production. Eur Respir J, 2008. 32(5): p. 1195-202.

MSDS

Material Safety Data Sheet Section1. Identification of the substance Product Name: Fudosteine Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:Fudosteine CAS number:13189-98-5 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Store in closed vessels, refrigerated. Storage: Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data No data Melting point: Flash point:No data Density:No data Molecular formula:C6H13NO3S Molecular weight:179.2 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, sulfur oxides. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xi