137863-89-9

• 常用中文名：缬沙坦烃化物
• 常用英文名：N-[(2'-Cyano-(1,1'-biphenyl)-4-yl)methyl)]valine methyl ester
• CAS号：137863-89-9
• 分子式：C₂₀H₂₂N₂O₂
• 分子量：322.401
• 发布时间：2018-09-30 16:09:22
• 更新时间：2024-01-02 18:21:47

名称

• 中文名: 缬沙坦烃化物
• 英文名: (S)-Methyl 2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoate
• 中文别名: N-[(2'-氰基-1,1'-联苯-4-基)甲基]-L-缬氨酸甲酯
• 英文别名: L-Valine, N-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-, methyl ester; methyl (2S)-2-[[4-(2-cyanophenyl)phenyl]methylamino]-3-methylbutanoate; N-[(2'-Cyano[1,1'-biphenyl]-4-yl)methyl]-L-valine Methyl Ester; Methyl (2S)-2-{[(2'-cyano-4-biphenylyl)methyl]amino}-3-methylbutanoate; Methyl N-[(2'-cyano-4-biphenylyl)methyl]-L-valinate; Methyl N-[(2'-cyanobiphenyl-4-yl)methyl]-L-valinate; MFCD08436153; N-[(2'-Cyano-(1,1'-biphenyl)-4-yl)methyl)]valine methyl ester; Valsartan Impurity 12

物化性质

• 密度: 1.12
• 沸点: 477.9±45.0 °C at 760 mmHg
• 分子式: C₂₀H₂₂N₂O₂
• 分子量: 322.401
• 闪点: 242.8±28.7 °C
• 精确质量: 322.168121
• PSA: 62.12000
• LogP: 4.00
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.571

安全

• 海关编码: 2926909090

合成路线

6306-52-1 114772-54-2 ~84% 137863-89-9

文献：Nie, Yong-Yan; Da, Ya-Jing; Zheng, Hao; Yang, Xiao-Xia; Jia, Lin; Wen, Cai-Hong; Liang, Li-Sha; Tian, Juan; Chen, Zhi-Long Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 8 p. 2747 - 2761

482577-59-3 ~% 137863-89-9

文献：WO2008/7391 A2, ; Page/Page column 16 ;

6306-52-1 135689-93-9 ~90% 137863-89-9

文献：Goossen, Lukas J.; Melzer, Bettina Journal of Organic Chemistry, 2007 , vol. 72, # 19 p. 7473 - 7476

3839-22-3 ~% 137863-89-9

文献：Journal of Organic Chemistry, , vol. 72, # 19 p. 7473 - 7476

131-63-5 ~% 137863-89-9

文献：Journal of Organic Chemistry, , vol. 72, # 19 p. 7473 - 7476

10602-01-4 ~% 137863-89-9

文献：Journal of Organic Chemistry, , vol. 72, # 19 p. 7473 - 7476

1122-91-4 ~% 137863-89-9

文献：Journal of Organic Chemistry, , vol. 72, # 19 p. 7473 - 7476

400747-06-0 ~% 137863-89-9

文献：Journal of Organic Chemistry, , vol. 72, # 19 p. 7473 - 7476

72-18-4 ~% 137863-89-9

文献：Bioorganic and Medicinal Chemistry, , vol. 20, # 8 p. 2747 - 2761

上下游产品

上游产品  9
6306-52-1 114772-54-2 482577-59-3 135689-93-9
3839-22-3 131-63-5 10602-01-4 1122-91-4
72-18-4
下游产品  1
137862-53-4

海关

海关编码	2926909090
中文概述	2926909090 其他腈基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%