2304-89-4

• 常用中文名：3-氧代-7a,12a-二羟基-5b-胆烷酸
• 常用英文名：3-​Oxocholic acid
• CAS号：2304-89-4
• 分子式：C₂₄H₃₈O₅
• 分子量：406.55600
• 相关类别： 研究领域 代谢疾病
• 发布时间：2018-12-23 13:00:12
• 更新时间：2026-07-17 13:19:46
• 3-Oxocholic acid 是一种氧胆汁酸的代谢产物,也是产气荚膜梭菌在肠道中由胆汁产生的主要降解产物。3-Oxocholic acid 是一种类固醇酸,主要存在于哺乳动物的胆汁中。

名称

• 中文名: 3-氧代脱氧胆酸
• 英文名: 7α,12α-dihydroxy-3-oxo-5β-cholan-24-oic acid methylester
• 中文别名: 3-酮基-7alpha,12alpha-二羟基-5alpha-胆烷酸; 3-Oxocholic acid #天然产物 HY-N7387; 3-去氢胆酸; 3-酮基-7Α,12Α-二羟基-5Α-胆烷酸; 3-氧代-7A,12A-二羟基-5B-胆烷酸; 胆酸杂质19; 3-氧脱氧胆酸; 3,脱氢胆酸
• 英文别名: 3-Oxo-7Alpha,12Alpha-hydroxy-5Beta-cholanoic Acid; 5β-CHOLANIC ACID-7α, 12α-DIOL-3-ONE; 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oic acid; 3-Oxocholic acid, 10 mM in DMSO; 3-Oxo-7α,12a-hydroxy-5-β-cholanoic Acid; (R)-4-((5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-10,13-dimethyl-3-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid; 7α,12α-dihydroxy-3-oxo-5β-cholan-24-oic acid; 3-Oxocholic acid; 3-Oxo-7α,12α-dihydroxy-5β-cholan-24-oic acid; 3-Keto-7alpha,12alpha-dihydroxy-5alpha-cholanic acid; 7Alpha,12Alpha-dihydroxy-3-oxo-5Beta-cholan-24-oic acid; 3-Oxo-7α,12α-hydroxy-5β-cholanoic Acid; Ursodeoxycholic Acid Impurity 12; 3-OXO DEOXYCHOLIC ACID; Cholan-24-oic acid, 7,12-dihydroxy-3-oxo-, (5β,7α,12α); 3-Oxo Deoxycholic Acid; 3-Oxo-7α,12α-dihydroxycholanic acid; 7α,12α-dihydroxy-3-oxo-5β-cholan-24-oicacidmethylester; 3-Oxo-7a,12a-dihydroxy-5b-cholanic acid; 3-Oxo-7±,12±-hydroxy-52-cholanoic Acid; 7,12-dihydroxy-3-oxocholanic acid; 7α,12α-Dihydroxy-3-oxo-5β-cholanic acid; 3-Ketocholic acid; 3-Oxo-7alpha,12alpha-hydroxy-5beta-cholanoic Acid; 4-(7,12-dihydroxy-10,13-dimethyl-3-oxo-1,2,4,5,6,7,8,9,11,12,14,15,16,17-te tradecahydrocyclopenta[a]phenanthren-17-yl)pentanoic acid

物化性质

• 密度: 1.180±0.06g/ml(Predicted)
• 沸点: 583.0±50.0℃(Predicted)
• 熔点: 185℃
• 分子式: C₂₄H₃₈O₅
• 分子量: 406.55600
• 精确质量: 406.27200
• PSA: 94.83000
• LogP: 3.65690
• 蒸汽压: 5.08E-16mmHg at 25°C
• 储存条件: 2-8℃，密闭，干燥

生物活性

• 描述: 3-Oxocholic acid 是一种氧胆汁酸的代谢产物,也是产气荚膜梭菌在肠道中由胆汁产生的主要降解产物。3-Oxocholic acid 是一种类固醇酸,主要存在于哺乳动物的胆汁中。
• 相关类别:
  研究领域 >> 代谢疾病
• 体内研究: 雄性Goto-Kakizaki(GK)大鼠接受回肠转位(IT)手术。在代谢组学分析中,与假IT大鼠相比,IT大鼠的3-氧胆酸增加[2]。
• 参考文献:

  [1]. Macdonald I, et al. Identification of 7alpha-, 12alpha-dihydroxy-3-oxo cholanoic acid as the major degradation product from cholic by C. perfringens. J Steroid Biochem. 1978 Apr;9(4):353-8.

  [2]. Yan K, et al. The Changes of Serum Metabolites in Diabetic GK Rats after Ileal Transposition Surgery. Obes Surg. 2019 Mar;29(3):882-890.

  [3]. Wahlström A, et al. Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism. Cell Metab. 2016 Jul 12;24(1):41-50.

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